AC T02072
XX
ID T02072
XX
DT 28.01.1997 (created); ewi.
DT 13.02.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA Msx-1
XX
SY Chox-7 (chick); Ghox-7 (chick); Hox-7; Hox-7.1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006440 Msx1.
XX
HO Msh (Drosophila) T03551.
XX
CL C0006; homeo; 3.1.2.11.1.
XX
SF 90% identity with human Msx-1 [2];
SF for DNA-binding, the three alpha-helices of the homeo domain are sufficient;
SF however, the less conserved N-terminal 10 AA residues of the homeo domain significantly stabilize DNA-binding by ensuring optimal folding of the whole domain [8];
XX
CP distal mesoderm of forelimb [4] [5], precursors of ciliary body in the optic cup [3], pituitary thyrotrophic cells during embryogenesis [13] [13] [3] [4] [5].
CN somatomammotropic cells [13].
XX
FF may play an important role in limb-pattern formation and for early differentiation of eye epithelium / development of ciliary body [3] [7];
FF can also function as repressor: for this function it does not require homeodomain DNA-binding sites [10];
FF interacts with protein complexes composed of TBP and TFIIA (DA) and TBP, TFIIA, and TFIIB (DAB) (in gel retardation assays), suggesting that the mechanism of repression is mediated through interactions with one or several components of the core transcription complex [10];
FF gene is induced in limb bud by a apical ectodermal signal [7];
FF expression in the neural plate (embryonal) is induced by BMP7 [9];
FF for expression in teeth, see [11];
FF part of signaling cascade of branchial arch development: Edn1 (endothelin-1) secretion stimulates Hand2 T04370 expression which regulates Msx1 expression in growing, distal brachial arches [12];
XX
IN T02409 Dlx-3; mouse, Mus musculus.
XX
MX M00394 V$MSX1_01.
MX M01412 V$MSX1_02.
MX M07298 V$MSX1_Q5.
MX M08822 V$MSX1_Q5_01.
XX
BS R61719.
BS R66262.
BS R66264.
BS R66265.
BS R62871.
BS R62875.
BS R61716.
BS R21487.
XX
DR TRANSPATH: MO000026138.
DR UniProtKB: P13297;
XX
RN [1]; RE0003871.
RX PUBMED: 8096059.
RA Catron K. M., Iller N., Abate C.
RT Nucleotides flanking a conserved TAAT core dictate the DNA binding specifity of three murine homeodomain proteins
RL Mol. Cell. Biol. 13:2354-2365 (1993).
RN [2]; RE0005151.
RX PUBMED: 1685479.
RA Hewitt J. E., Clarke L. E., Iven A., Williamson R.
RT Structure and sequence of the human homeobox gene HOX7
RL Genomics 11:670-678 (1991).
RN [3]; RE0005152.
RX PUBMED: 1682128.
RA Monaghan A. P., Davidson D. R., Sime C. M., Graham E., Baldock R., Bhattacharya S. S., Hill R. E.
RT The Msh-like homeobox genes define domains in the developing vertebrate eye
RL Development 112:1053-1061 (1991).
RN [4]; RE0005153.
RX PUBMED: 2565278.
RA Hill R. E., Jones P. F., Rees A. R., Sime C. M., Justice M. J., Copeland N. G., Jenkins N. A., Graham E., Davidson D. R.
RT A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1
RL Genes Dev. 3:26-37 (1989).
RN [5]; RE0005154.
RX PUBMED: 2565810.
RA Robert B., Sassoon D., Jacq B., Gehring W., Buckingham M.
RT Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis
RL EMBO J. 8:91-100 (1989).
RN [6]; RE0005155.
RX PUBMED: 1673109.
RA Holland P. W.
RT Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian
RL Gene 98:253-257 (1991).
RN [7]; RE0005159.
RX PUBMED: 1677742.
RA Davidson D. R., Crawley A., Hill R. E., Tickle C.
RT Position-dependent expression of two related homeobox genes in developing vertebrate limbs
RL Nature 352:429-431 (1991).
RN [8]; RE0005160.
RX PUBMED: 7915838.
RA Shang Z., Isaac V. E., Li H., Patel L., Catron K. M., Curran T., Montelione G. T., Abate C.
RT Design of a 'minimAl' homeodomain: The N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure
RL Proc. Natl. Acad. Sci. USA 91:8373-8377 (1994).
RN [9]; RE0006697.
RX PUBMED: 9226442.
RA Shimamura K., Rubenstein J. L. R.
RT Inductive interactions direct early regionalization of the mouse forebrain
RL Development 124:2709-2718 (1997).
RN [10]; RE0010105.
RX PUBMED: 7823952.
RA Catron K. M., Zhang H., Marshall S. C., Inostroza J. A., Wilson J. M., Abate C.
RT Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites
RL Mol. Cell. Biol. 15:861-871 (1995).
RN [11]; RE0014818.
RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I.
RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/MSX1.htm
RL Internet : (1996).
RN [12]; RE0015954.
RX PUBMED: 9671575.
RA Thomas T., Kurihara H., Yamagishi H., Kurihara Y., Yazaki Y., Olson E. N., Srivastava D.
RT A signaling cascade involving endothelin-1, dHAND and Msx1 regulates development of neural-crest-derived branchial arch mesenchyme
RL Development 125:3005-3014 (1998).
RN [13]; RE0024536.
RX PUBMED: 9369446.
RA Sarapura V. D., Strouth H. L., Gordon D. F., Wood W. M., Ridgway E. C.
RT Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter.
RL Mol. Endocrinol. 11:1782-1794 (1997).
RN [14]; RE0048997.
RX PUBMED: 16678795.
RA Gupta V., Bei M.
RT Modification of Msx1 by SUMO-1.
RL Biochem. Biophys. Res. Commun. 345:74-77 (2006).
XX
//