AC T02122
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ID T02122
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DT 21.05.1997 (created); hiwi.
DT 07.08.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA TAFII80
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SY p85; TAF(II)78; TAF(II)80; TAF-80.
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OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
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HO TAF(II)100 (human), TAF(II)90 (yeast).
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SZ 704 AA; 79.3 kDa (cDNA) (calc.), 80 kDa (SDS) [2], 85 kDa (SDS) [3] [3] [2]
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SQ MSLEVSNINGGNGTQLSHDKRELLCLLKLIKKYQLKSTEELLCQEANVSSVELSEISESD
SQ VQQVLGAVLGAGDANRERKHVQSPAQGHKQSAVTEANAAEELAKFIDDDSFDAQHYEQAY
SQ KELRTFVEDSLDIYKHELSMVLYPILVQIYFKILASGLREKAKEFIEKYKCDLDGYYIEG
SQ LFNLLLLSKPEELLENDLVVAMEQDKFVIRMSRDSHSLFKRHIQDRRQEVVADIVSKYLH
SQ FDTYEGMARNKLQCVATAGSHLGEAKRQDNKMRVYYGLLKEVDFQTLTTPAPAPEEEDDD
SQ PDAPDRPKKKKPKKDPLLSKKSKSDPNAPSIDRIPLPELKDSDKLLKLKALREASKRLAL
SQ SKDQLPSAVFYTVLNSHQGVTCAEISDDSTMLACGFGDSSVRIWSLTPAKLRTLKDADSL
SQ RELDKESADINVRMLDDRSGEVTRSLMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLWSLL
SQ TWSCVVTYRGHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCV
SQ QFHPNSNYVATGSSDRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNI
SQ IIWDLSNGSLVTTLLRHTSTVTTITFSRDGTVLAAAGLDNNLTLWDFHKVTEDYISNHIT
SQ VSHHQDENDEDVYLMRTFPSKNSPFVSLHFTRRNLLMCVGLFKS
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SC Swiss-Prot#P49846
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FT 32 370 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 96 242 
PF04494; WD40 associated region in TFIID subunit.
FT 364 688 
beta-transducin repeats [2].
FT 367 405 
SM00320; WD40_4.
FT 369 405 
PF00400; WD40.
FT 373 414 
PS50082; WD_REPEATS_2.
FT 373 414 
PS50294; WD_REPEATS_REGION.
FT 427 655 
PS50294; WD_REPEATS_REGION.
FT 439 478 
SM00320; WD40_4.
FT 441 478 
PF00400; WD40.
FT 446 487 PS50082; WD_REPEATS_2.
FT 481 520 SM00320; WD40_4.
FT 483 520 PF00400; WD40.
FT 488 529 PS50082; WD_REPEATS_2.
FT 523 562 SM00320; WD40_4.
FT 525 562 PF00400; WD40.
FT 530 571 PS50082; WD_REPEATS_2.
FT 565 604 SM00320; WD40_4.
FT 567 604 PF00400; WD40.
FT 572 613 PS50082; WD_REPEATS_2.
FT 607 646 SM00320; WD40_4.
FT 609 646 PF00400; WD40.
FT 614 646 PS50082; WD_REPEATS_2.
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SF contains 7-8 beta tansducin (or WD) repeats [2] [3];
SF 22% identity / 45% similarity with COP1 gene product of Arabidopsis which exerts developmental regulation;
SF pI(calc.) = 5.8 [2];
SF direct interaction with TBP and TAF(II)110, depending on the beta-transducin repeats [3];
SF may recognize a preassembled complex of TBP, C-terminal TAF(II)250, TAF(II)110 and TAF(II)60 [2];
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FF part of the TFIID complex [2] [3];
FF may act as a transcriptional co-activator;
FF may be competed by another WD40-repeat protein, Esc (extra sex combs) [1];
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IN T02121 TAFII110; fruit fly, Drosophila melanogaster.
IN T00797 TBP; fruit fly, Drosophila melanogaster.
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DR TRANSPATH: MO000045986.
DR EMBL: U06460; DM06460.
DR UniProtKB: P49846; T2D3_DROME.
DR FLYBASE: FBgn0010356; Taf80.
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RN [1]; RE0005604.
RX PUBMED: 7556071.
RA Gutjahr T., Frei E., Spicer C., Baumgartner S., White R. A. H., Noll M.
RT The polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family
RL EMBO J. 14:4296-4306 (1995).
RN [2]; RE0005605.
RX PUBMED: 8483503.
RA Dynlacht B. D., Weinzierl R. O. J., Admon A., Tjian R.
RT The dTAFII80 subunit of Drosophila TFIID contains 8-transducin repeats
RL Nature 363:176-179 (1993).
RN [3]; RE0005606.
RX PUBMED: 8247000.
RA Kokubo T., Gong D.-W., Yamashita S., Takada R., Roeder R. G., Horikoshi M., Nakatani Y.
RT Molecular cloning, expression, and characterization of the Drosophila 85-kilodalton TFIID subunit
RL Mol. Cell. Biol. 13:7859-7863 (1993).
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