AC T02121
XX
ID T02121
XX
DT 21.05.1997 (created); hiwi.
DT 07.08.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA TAFII110
XX
SY TAF(II)110.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
SZ 921 AA; 99.3 kDa (cDNA) (calc.), 110 kDa (SDS) [4] [2]
XX
SQ MNTSQTAAGNRITFTSQPLPNGTISIAGNPGAVISTAQLPNTTTIKTIQAGIGGQHQGLQ
SQ QVHHVQQQQQSQQQQQQQQQTQSAGQPLLNSMLPAGVVVGMRQQAPSQQQQKNVPTNPLS
SQ RVVINSHMAGVRPQSPSITLSTLNTGQTPALLVKTDNGFQLLRVGTTTGPPTVTQTITNT
SQ SNNSNTTSTTNHPTTTQIRLQTVPAAASMTNTTATSNIIVNSVASSGYANSSQPPHLTQL
SQ NAQAPQLPQITQIQTIPAQQSQQQQVNNVSSAGGTATAVSSTTAATTTQQGNTKEKCRKF
SQ LANLIELSTREPKPVEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQPCLIGFLKKSL
SQ PLLRQALYTKELVIEGIKPPPQHVLGLAGLSQQLPKIQAQIRPIGPSQTTTIGQTQVRMI
SQ TPNALGTPRPTIGHTTISKQPPNIRLPTAPRLVNTGGIRTQIPSLQVPGQANIVQIRGPQ
SQ HAQLQRTGSVQIRATTRPPNSVPTANKLTAVKVGQTQIKAITPSLHPPSLAAISGGPPPT
SQ PTLSVLSTLNSASTTTLPIPSLPTVHLPPEALRAREQMQNSLNHNSNHFDAKLVEIKAPS
SQ LHPPHMERINASLTPIGAKTMARPPPAINKAIGKKKRDAMEMDAKLNTSSGGAASAANSF
SQ FQQSSMSSMYGDDDINDVAAMGGVNLAEESQRILGCTENIGTQIRSCKDEVFLNLPSLQA
SQ RIRAITSEAGLDEPSQDVAVLISHACQERLKNIVEKLAVIAEHRIDVIKLDPRYEPAKDV
SQ RGQIKFLEELDKAEQKRHEELEREMLLRAAKSRSRVEDPEQAKMKARAKEMQRAEMEELR
SQ QRDANLTALQAIGPRKKLKLDGETVSSGAGSSGGGVLSSSGSAPTTLRPRIKRVNLRDML
SQ FYMEQEREFCRSSMLFKTYLK
XX
SC Swiss-Prot#P47825
XX
FT 1 308 
interacting with Sp1 [7].
FT 10 332 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 290 386 
PS51119; TAFH.
FT 291 386 
PF07531; NHR1 homology to TAF.
FT 293 383 
SM00549; nervy_1.
FT 373 787 
binding to PR [6].
FT 572 921 
binding TAFII30 [5].
FT 675 921 
PF05236; Transcription initiation factor TFIID compon.
XX
SF no direct interaction with TBP but with the N-terminal part of TAF(II)250 [1] [4];
SF strongly interacts with TAF(II)30alpha [5];
SF N-terminal third can interact with the mammalian factor Sp1 [1] [7] [8];
SF pI(calc.) = 10.1 [7];
XX
FF part of the TFIID complex;
FF triple complex of TBP, TAF(II)250 and TAFII110 is sufficient to confer activation by Sp1 [1] [4];
FF TAFII110 may thus be considered as a coactivator [7];
XX
IN T00696 PR B; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T02119 TAFII250; fruit fly, Drosophila melanogaster.
IN T02126 TAFII30alpha; fruit fly, Drosophila melanogaster.
IN T02122 TAFII80; fruit fly, Drosophila melanogaster.
IN T02157 TFIIA; fruit fly, Drosophila melanogaster.
XX
DR TRANSPATH: MO000045985.
DR EMBL: L06861; DMTAF110X.
DR EMBL: S63550; S63550.
DR UniProtKB: P47825; T2D2_DROME.
DR FLYBASE: FBgn0010280; Taf110.
XX
RN [1]; RE0005568.
RX PUBMED: 8464492.
RA Weinzierl R. O. J., Dynlacht B. D., Tjian R.
RT Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator
RL Nature 362:511-517 (1993).
RN [2]; RE0005569.
RX PUBMED: 8349634.
RA Kokubo T., Takada R., Yamashita S., Gong D.-W., Roeder R. G., Horikoshi M., Nakatani Y.
RT Identification of TFIID components required for transcriptional activation by upstream stimulatory factor
RL J. Biol. Chem. 268:17554-17558 (1993).
RN [3]; RE0005570.
RX PUBMED: 7545910.
RA Kokubo T., Gong D.-W., Wootton J. C., Horikoshi M., Roeder R. G., Nakatani Y.
RT Molecular cloning of Drosophila TFIID subunits
RL Nature 367:484-487 (1994).
RN [4]; RE0005599.
RX PUBMED: 8327460.
RA Kokubo T., Gong D.-W., Roeder R. G., Horikoshi M., Nakatani Y.
RT The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N-terminal region of the 230-kDa subunit
RL Proc. Natl. Acad. Sci. USA 90:5896-5900 (1993).
RN [5]; RE0005600.
RX PUBMED: 8276241.
RA Yokomori K., Chen J.-L., Zhou S., Tjian R.
RT Molecular cloning and characterization of dTAFII30alpha and dTAFII308beta: two small subunits of Drosophila TFIID
RL Genes Dev. 7:2587-2597 (1993).
RN [6]; RE0005601.
RX PUBMED: 7673170.
RA Schwerk C., Klotzbuecher M., Sachs M., Ulber V., Klein-Hitpass L.
RT Identification of transactivation function in the progesterone receptor that interacts with the TAFII110 subunit of the TFIID complex
RL J. Biol. Chem. 270:21331-21338 (1995).
RN [7]; RE0005602.
RX PUBMED: 7678780.
RA Hoey T., Weinzierl R. O. J., Gill G., Chen J.-L., Dynlacht B. D., Tjian R.
RT Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators
RL Cell 72:247-260 (1993).
RN [8]; RE0005603.
RX PUBMED: 8278363.
RA Gill G., Pascal E., Tseng Z. H., Tjian R.
RT A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation
RL Proc. Natl. Acad. Sci. USA 91:192-196 (1994).
XX
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