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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T02119 XX ID T02119 XX DT 21.05.1997 (created); hiwi. DT 07.08.2013 (updated); mkl. CO Copyright (C), QIAGEN. XX FA TAFII250 XX SY p230; p250; TAF(II)250; TAF-230. XX OS fruit fly, Drosophila melanogaster OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae XX SZ 2068 AA; 232.5 kDa (cDNA) (calc.), 250 kDa (SDS), 230 kDa (SDS) XX SQ MEMESDNSDDEGSIGNGLDLTGILFGNIDSEGRLLQDDDGEGRGGTGFDAELRENIGSLS SQ KLGLDSMLLEVIDLKEAEPPSDDEEEEDARPSAVSASGGMSAFDALKAGVKREEREDGAV SQ KAQDDAIDYSDITELSEDCPRTPPEETSTYDDLEDAIPASKVEAKLTKDDKELMPPPSAP SQ MRSGSGGGIEEPAKSNDASSPSDDSKSTDSKDADRKLDTPLADILPSKYQNVDVRELFPD SQ FRPQKVLRFSRLFGPGKPTSLPQIWRHVRQSRRKRNQSRDQKTTNTGGSDSPSDTEEPRK SQ RGFSLHYAAEPTPAECMSDDEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQI SQ WYDILEVPDSGEGFNYGFKTKAASTSSQQQLKDERRVKSPEDDVEDPSIADDAFLMVSQL SQ HWEDDVVWDGNDIKAKVLQKLNSKTNAAGWLPSSGSRTAGAFSQPGKPSMPVGSGSSKQG SQ SGASSKKAQQNAQAKPAEAPDDTWYSLFPVENEELIYYKWEDEVIWDAQQVSKVPKPKVL SQ TLDPNDENIILGIPDDIDPSKINKSTGPPPKIKIPHPHVKKSKILLGKAGVINVLAEDTP SQ PPPPKSPDRDPFNISNDTYYTPKTEPTLRLKVGGNLIQHSTPVVELRAPFVPTHMGPMNV SQ RAFHRPPLKKYSHGPMAQSIPHPVFPLLKTIAKKAKQREVERIASGGGDVFFMRNPEDLS SQ GRDGDIVLAEFCEEHPPLINQVGMCSKIKNYYKRKAEKDSGPQDYVYGEVAFAHTSPFLG SQ ILHPGQCIQAIENNMYRAPIYPHKMAHNDFLVIRTRNNYWIRSVNSIYTVGQECPLYEVP SQ GPNSKRANNFTRDFLQVFIYRLFWKSRDNPRRIRMDDIKQAFPAHSESSIRKRLKQCADF SQ KRTGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYFSMIAAEQRLKDAGYGEKFLFAPQ SQ EDDDEEAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNKP SQ TQTKEEQESQPKRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLS SQ TEKAKAGEEGMDKFSRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSAS SQ EESDLEELGKNLENMLSNKKTSTQLSREREELERQELLRQLDEEHGGPSGSGGAKGAKGK SQ DDPGQQMLATNNQGRILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQ SQ FATLDEQQKEEMKREKRRIQEQLRRIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSSG SQ GHSHKERDSGYKEVSPSRKKFKLKPDLKLKCGACGQVGHMRTNKACPLYSGMQSSLSQSN SQ PSLADDFDEQSEKEMTMDDDDLVNVDGTKVTLSSKILKRHGGDDGKRRSGSSSGFTLKVP SQ RDAMGKKKRRVGGDLHCDYLQRHNKTANRRRTDPVVVLSSILEIIHNELRSMPDVSPFLF SQ PVSAKKVPDYYRVVTKPMDLQTMREYIRQRRYTSREMFLEDLKQIVDNSLIYNGPQSAYT SQ LAAQRMFSSCFELLAEREDKLMRLEKAINPLLDDDDQVALSFIFDKLHSQIKQLPESWPF SQ LKPVNKKQVKDYYTVIKRPMDLETIGKNIEAHRYHSRAEYLADIELIATNCEQYNGSDTR SQ YTKFSKKILEYAQTQLIEFSEHCGQLENNIAKTQERARENAPEFDEAWGNDDYNFDRGSR SQ ASSPGDDYIDVEGHGGHASSSNSIHRSMGAEAGSSHTAPAVRKPAPPGPGEVKRGRGRPR SQ KQRDPVEEDLQCSTDDEDDDEEEDFQEVSEDENNAASILDQGERINAPADAMDGMFDPKN SQ IKTEIDLEAHQMADESMDVDPNYDPSDFLAMHKQRQSLGEPSSLQGAFTNFLSHEQDDNG SQ PYNPAEASTSAASGADLGMDASMAMQMAPEMPVNTMNNGMGIDDDLDISESDEEDDGSRV SQ RIKKEVFDDGDYALQHQQMGQAASQSQIYMVDSSNEPTTLDYQQPPQLDFQQVQEMEQLQ SQ HQVMPPMQSEQLQQQQTPQGDNDYAWTF XX SC Swiss-Prot#P51123 XX FT 1 342 interaction with TAF-110 [11]. FT 146 986 PF00478; IMP dehydrogenase / GMP reductase domain. FT 1247 1360 HMG box homology [4]. FT 1471 1579 SM00297; bromo_6. FT 1478 1565 PF00439; Bromodomain. FT 1490 1560 PS50014; BROMODOMAIN_2. FT 1593 1701 SM00297; bromo_6. FT 1600 1687 PF00439; Bromodomain. FT 1612 1682 PS50014; BROMODOMAIN_2. FT 1793 1805 PF02178; AT_hook. XX SF interacts with TBP through two regions thereby inhibiting DNA-binding by TBP in the absence of other TAFs; SF for this, the binding site within the N-terminal 80 amino acid residues is responsible [3] [10]; SF most other TAFs interact with TAFII250; SF doubtful significance of the HMG homology region [4]; XX FF tight association with TBP, contributes to TFIID assembly; FF confers promoter selectivity to TBP-TAF complexes (TFIID subcomplexes) together with TAF(II)150 in mediating the requirement for initiator and additional downstream elements [8]; FF function may partially be substituted by SV40 large T antigen [9]; XX IN T01269 Taf2p; yeast, Saccharomyces cerevisiae. IN T02121 TAFII110; fruit fly, Drosophila melanogaster. IN T02120 TAFII150; fruit fly, Drosophila melanogaster. IN T02131 TAFII30beta; fruit fly, Drosophila melanogaster. IN T02124 TAFII60; fruit fly, Drosophila melanogaster. IN T00797 TBP; fruit fly, Drosophila melanogaster. XX DR TRANSPATH: MO000045983. DR EMBL: S61883; S61883. DR UniProtKB: P51123; CCG1_DROME. DR FLYBASE: FBgn0010355; Taf250. XX RN [1]; RE0005557. RX PUBMED: 1657708. RA Pugh B. F., Tjian R. RT Transcription from a TATA-less promoter requires a multisubunit TFIID complex RL Genes Dev. 5:1935-1945 (1991). RN [2]; RE0005560. RX PUBMED: 8262073. RA Weinzierl R. O. J., Ruppert S., Dynlacht B. D., Tanese N., Tjian R. RT Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID RL EMBO J. 12:5303-5309 (1993). RN [3]; RE0005567. RX PUBMED: 8170939. RA Kokubo T., Yamashita S., Horikoshi M., Roeder R. G., Nakatani Y. RT Interaction between the N-terminal domain of the 230-kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA-box binding RL Proc. Natl. Acad. Sci. USA 91:3520-3524 (1994). RN [4]; RE0005568. RX PUBMED: 8464492. RA Weinzierl R. O. J., Dynlacht B. D., Tjian R. RT Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator RL Nature 362:511-517 (1993). RN [5]; RE0005569. RX PUBMED: 8349634. RA Kokubo T., Takada R., Yamashita S., Gong D.-W., Roeder R. G., Horikoshi M., Nakatani Y. RT Identification of TFIID components required for transcriptional activation by upstream stimulatory factor RL J. Biol. Chem. 268:17554-17558 (1993). RN [6]; RE0005570. RX PUBMED: 7545910. RA Kokubo T., Gong D.-W., Wootton J. C., Horikoshi M., Roeder R. G., Nakatani Y. RT Molecular cloning of Drosophila TFIID subunits RL Nature 367:484-487 (1994). RN [7]; RE0005571. RX PUBMED: 8178153. RA Verrijzer C. P., Yokomori K., Chen J.-L., Tjian R. RT Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA RL Science 264:933-941 (1994). RN [8]; RE0005596. RX PUBMED: 7600579. RA Verrijzer C. P., Chen J.-L., Yokomori K., Tjian R. RT Binding of TAFs to Core Elements Directs Promotor Selectivity by RNA Polymerase II RL Cell 81:1115-1125 (1995). RN [9]; RE0005597. RX PUBMED: 8647434. RA Damania B., Alwine J. C. RT TAF-like function of SV40 large T antigen RL Genes Dev. 10:1369-1381 (1996). RN [10]; RE0005598. RX PUBMED: 8504928. RA Kokubo T., Gong D.-W., Yamashita S., Horikoshi M., Roeder R. G., Nakatani Y. RT Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID RL Genes Dev. 7:1033-1046 (1993). RN [11]; RE0005599. RX PUBMED: 8327460. RA Kokubo T., Gong D.-W., Roeder R. G., Horikoshi M., Nakatani Y. RT The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N-terminal region of the 230-kDa subunit RL Proc. Natl. Acad. Sci. USA 90:5896-5900 (1993). RN [12]; RE0005600. RX PUBMED: 8276241. RA Yokomori K., Chen J.-L., Zhou S., Tjian R. RT Molecular cloning and characterization of dTAFII30alpha and dTAFII308beta: two small subunits of Drosophila TFIID RL Genes Dev. 7:2587-2597 (1993). XX //