AC T02124
XX
ID T02124
XX
DT 21.05.1997 (created); hiwi.
DT 07.08.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA TAFII60
XX
SY p62; TAF(II)60.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
HO TAF(II)70 (human).
XX
CL C0030; histone fold.
XX
SZ 592 AA; 64.3 kDa (cDNA) (calc.), 62 kDa (SDS) [2]
XX
SQ MLYGSSISAESMKVIAESIGVGSLSDDAAKELAEDVSIKLKRIVQDAAKFMNHAKRQKLS
SQ VRDIDMSLKVRNVEPQYGFVAKDFIPFRFASGGGRELHFTEDKEIDLGEITSTNSVKIPL
SQ DLTLRSHWFVVEGVQPTVPENPPPLSKDSQLLDSVNPVIKMDQGLNKDAAGKPTTGKIHK
SQ LKNVETIHVKQLATHELSVEQQLYYKEITEACVGSDEPRRGEALQSLGSDPGLHEMLPRM
SQ CTFIAEGVKVNVVQNNLALLIYLMRMVRALLDNPSLFLEKYLHELIPSVMTCIVSKQLCM
SQ RPELDNHWALRDFASRLMAQICKNFNTLTNNLQTRVTRIFSKALQNDKTHLSSLYGSIAG
SQ LSELGGEVIKVFIIPRLKFISERIEPHLLGTSISNTDKTAAGHIRAMLQKCCPPILRQMR
SQ SAPDTAEDYKNDFGFLGPSLCQAVVKVRNAPASSIVTLSSNTINTAPITSAAQTATTIGR
SQ VSMPTTQRQGSPGVSSLPQIRAIQANQPAQKFVIVTQNSPQQGQAKVVRRGSSPHSVVLS
SQ AASNAASASNSNSSSSGSLLAAAQRSSENVCVIAGSEAPAVDGITVQSFRAS
XX
SC Swiss-Prot#P49847
XX
FT 5 69 
PF02969; TATA box binding protein associated factor (.
FT 8 71 
PS50028; HIST_TAF.
FT 146 439 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 285 383 
PF07571; Protein of unknown function (DUF1546).
XX
SF pI(calc.) = 9.4 [1];
SF weak interaction with TBP [1] [3];
SF contradictory results about interaction with C-terminal TAF(II)250 [1] [3];
SF no interaction with TAF(II)110 or TAF(II)80 [3];
SF together with the histone H3-like region within TAF(II)40, the histone fold of TAFII60 may wrap DNA into a nucleosome-like structure, possibly facilitating histone displacement from the transcribed DNA [3];
XX
FF part of the TFIID complex;
FF function may be to recruit TAF(II)40 [1];
XX
IN T02119 TAFII250; fruit fly, Drosophila melanogaster.
IN T02125 TAFII40; fruit fly, Drosophila melanogaster.
IN T00797 TBP; fruit fly, Drosophila melanogaster.
XX
DR TRANSPATH: MO000045987.
DR EMBL: L25443; DMTAF2A.
DR EMBL: U06459; DM06459.
DR UniProtKB: P49847; T2D4_DROME.
DR FLYBASE: FBgn0010417; Taf60.
XX
RN [1]; RE0005560.
RX PUBMED: 8262073.
RA Weinzierl R. O. J., Ruppert S., Dynlacht B. D., Tanese N., Tjian R.
RT Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID
RL EMBO J. 12:5303-5309 (1993).
RN [2]; RE0005569.
RX PUBMED: 8349634.
RA Kokubo T., Takada R., Yamashita S., Gong D.-W., Roeder R. G., Horikoshi M., Nakatani Y.
RT Identification of TFIID components required for transcriptional activation by upstream stimulatory factor
RL J. Biol. Chem. 268:17554-17558 (1993).
RN [3]; RE0005570.
RX PUBMED: 7545910.
RA Kokubo T., Gong D.-W., Wootton J. C., Horikoshi M., Roeder R. G., Nakatani Y.
RT Molecular cloning of Drosophila TFIID subunits
RL Nature 367:484-487 (1994).
RN [4]; RE0005607.
RX PUBMED: 8221891.
RA Goodrich J. A., Hoey T., Thut C. J., Admon A., Tjian R.
RT Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB
RL Cell 75:519-530 (1993).
XX
//