AC T02207
XX
ID T02207
XX
DT 29.07.1997 (created); ewi.
DT 06.08.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA TAFII250-delta
XX
SY TBP-associated factor 250 Delta.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G009204 TAF1; HGNC: TAF1.
XX
CL C0015; HMG.
XX
SZ 1666 AA; 189.4 kDa (calc.).
XX
SQ MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
SQ ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
SQ SRRYQQTMGSLQPLCHSDYDEDDYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFR
SQ KLEENNGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAM
SQ AYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPND
SQ ENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWN
SQ LSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFG
SQ ALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEE
SQ NGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENN
SQ LFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDF
SQ LQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKS
SQ DFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDE
SQ VRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKK
SQ TVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSK
SQ FARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIEN
SQ MLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLK
SQ IYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRR
SQ IQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTN
SQ APPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFP
SQ KQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFH
SQ TPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSL
SQ TQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSW
SQ PFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPE
SQ SQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQP
SQ PDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQ
SQ PQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQ
SQ ENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVS
SQ EEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
XX
FT 287 795 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 465 480 
sigma4.1 homology region [2].
FT 760 940 
SWI4 homology region [2].
FT 794 804 
sigma2.1 homology region [2].
FT 914 1004 
binding of TFIIF-alpha [3].
FT 1005 1033 
sigma4.2 homology region [2].
FT 1172 1280 
SM00297; bromo_6.
FT 1179 1266 
PF00439; Bromodomain.
FT 1191 1261 
PS50014; BROMODOMAIN_2.
FT 1294 1403 
SM00297; bromo_6.
FT 1301 1389 PF00439; Bromodomain.
FT 1314 1384 PS50014; BROMODOMAIN_2.
XX
SF probable splice variants are TAF(II)250 T00781 and CCG1 T02206 [1];
XX
DR TRANSPATH: MO000026225.
XX
RN [1]; RE0005584.
RX PUBMED: 7680771.
RA Ruppert S., Wang E. H., Tjian R.
RT Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation
RL Nature 362:175-179 (1993).
RN [2]; RE0005585.
RX PUBMED: 8450888.
RA Hisatake K., Hasegawa S., Takada R., Nakatani Y., Horikoshi M., Roeder R. G.
RT The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1
RL Nature 362:179-181 (1993).
RN [3]; RE0005590.
RX PUBMED: 7590250.
RA Ruppert S., Tjian R.
RT Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation
RL Genes Dev. 9:2747-2755 (1995).
XX
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