AC T02206
XX
ID T02206
XX
DT 29.07.1997 (created); ewi.
DT 06.08.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA TAFII250-isoform1
XX
SY CCG1; cell cycle gene 1; p250; TAFII250; TBP-associated factor 250.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G009204 TAF1; HGNC: TAF1.
XX
CL C0015; HMG; 4.1.3.0.5.1.
XX
SZ 1872 AA; 212.7 kDa (cDNA) (calc.), 250 kDa (SDS) [2] [4] [1]
XX
SQ MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
SQ ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
SQ SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV
SQ DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR
SQ FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP
SQ PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS
SQ GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED
SQ VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW
SQ EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI
SQ LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ
SQ PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG
SQ EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG
SQ ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF
SQ VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES
SQ SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD
SQ AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG
SQ EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL
SQ SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST
SQ EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA
SQ SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT
SQ KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL
SQ KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG
SQ TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD
SQ PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP
SQ SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD
SQ DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH
SQ KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT
SQ AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT
SQ PEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSA
SQ IQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISY
SQ GSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFH
SQ SIAGDSDLDSDE
XX
SC Swiss-Prot#P21675-1
XX
FT 1 177 
NF-kappaB homology region [4].
FT 146 351 
not found in TAF(II)250delta [3].
FT 493 1001 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 671 686 
sigma4.1 homology region [4].
FT 966 1146 
SWI4 homology region [4].
FT 1000 1010 
sigma2.1 homology region [4].
FT 1120 1210 
binding of TFIIF-alpha [9].
FT 1211 1239 
sigma4.2 homology region [4].
FT 1378 1486 
SM00297; bromo_6.
FT 1385 1472 
PF00439; Bromodomain.
FT 1397 1467 PS50014; BROMODOMAIN_2.
FT 1500 1609 SM00297; bromo_6.
FT 1507 1595 PF00439; Bromodomain.
FT 1520 1590 PS50014; BROMODOMAIN_2.
XX
SF probable splice variants are TAF(II)250 T00781 and TAF(II)250Delta T02207 [3];
XX
FF essential for cell cycle progression through G1 phase [8];
XX
IN T08520 TBP-isoform1; human, Homo sapiens.
XX
DR TRANSPATH: MO000046075.
DR EMBL: D90359; HSCCG1B.
DR EMBL: X07024; HSCCG1.
DR UniProtKB: P21675-1; TAF1_HUMAN.
XX
RN [1]; RE0005559.
RX PUBMED: 8436290.
RA Zhou Q., Boyer T. G., Berk A. J.
RT Factors (TAFs) required for activated transcription interact with TATA box-binding protein conserved core domain
RL Genes Dev. 7:180-187 (1993).
RN [2]; RE0005583.
RX PUBMED: 8183347.
RA Kim T. K., Hashimoto S., Kelleher III R. J., Flanagan P. M., Kornberg R. D., Horikoshi M., Roeder R. G.
RT Effects of activation-defective TBP mutations on transcription initiation in yeast
RL Nature 369:252-255 (1994).
RN [3]; RE0005584.
RX PUBMED: 7680771.
RA Ruppert S., Wang E. H., Tjian R.
RT Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation
RL Nature 362:175-179 (1993).
RN [4]; RE0005585.
RX PUBMED: 8450888.
RA Hisatake K., Hasegawa S., Takada R., Nakatani Y., Horikoshi M., Roeder R. G.
RT The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1
RL Nature 362:179-181 (1993).
RN [5]; RE0005586.
RX PUBMED: 3169001.
RA Sekiguchi T., Miyata T., Nishimoto T.
RT Molecular cloning of the cDNA of human X chromosomal gene (CCG1) which complement the temperature sensitive G1 mutants, tsBN462 and ts13 of BHK cells
RL EMBO J. 7:1683-1687 (1988).
RN [6]; RE0005587.
RX PUBMED: 1350857.
RA Haynes S. R., Dollard C., Winston F., Beck S., Trowsdale J., Dawid I. B.
RT The bromodomain: A conserved sequence found in human, Drosophila and yeast proteins
RL Nucleic Acids Res. 20:2603-2603 (1992).
RN [7]; RE0005588.
RX PUBMED: 2038334.
RA Sekiguchi T., Nohiro Y., Nakamura Y., Hisamoto N., Nishimoto T.
RT The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein
RL Mol. Cell. Biol. 11:3317-3325 (1991).
RN [8]; RE0005589.
RX PUBMED: 8303298.
RA Wang E., Tjian R.
RT Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250
RL Science 263:811-814 (1994).
RN [9]; RE0005590.
RX PUBMED: 7590250.
RA Ruppert S., Tjian R.
RT Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation
RL Genes Dev. 9:2747-2755 (1995).
RN [10]; RE0047734.
RX PUBMED: 9388200.
RA Leveillard T., Wasylyk B.
RT The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter.
RL J. Biol. Chem. 272:30651-30661 (1997).
RN [11]; RE0049459.
RX PUBMED: 15637059.
RA Boyer-Guittaut M., Birsoy K., Potel C., Elliott G., Jaffray E., Desterro J. M., Hay R. T., Oelgeschlager T.
RT SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5.
RL J. Biol. Chem. 280:9937-9945 (2005).
XX
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