AC T02225
XX
ID T02225
XX
DT 24.10.1997 (created); ewi.
DT 24.10.1997 (updated); ewi.
CO Copyright (C), QIAGEN.
XX
FA TFIIA-L
XX
SY dTFIIA-L; TFIIA-alpha/beta precursor; TFIIA-LN/LC.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
HO TFIIA-alpha/beta precursor (human), TOA1 (yeast).
XX
SZ 366 AA; 39.2 kDa (cDNA) (calc.), 48 kDa (alpha/beta precursor), 30 kDa (alpha), 20 kDa (beta) (SDS) [2]
XX
SQ MALCQTSVLKVYHAVIEDVITNVRDGFLDEGVDEQVLQEMKQVWRNKLLASKAVELSPDS
SQ GDGSHPPPIVANNPKSHKAANAKAKKAAAATAVTSHQHIGGNSSMSSLVGLKSSAGMAAG
SQ SGIRNGLVPIKQEVNSQNPPPLHPTSGASMMQKQQQAASSGQGSIPIVATLDPNRIMPVN
SQ ITLPSPAGSASSESRVLTIQVPASALQENQLTQILTAHLISSIMSLPTTLASSVLQQHVN
SQ AALSSANHQKTLAAAKQLDGALDSSDEDESEESDDNIDNDDDDDLDKDDDEDAEHEDAAE
SQ EEPLNSEDDVTDEDSAEMFDTDNVIVCQYDKITRSRNKWKFYLKDGIMNMRGKDYVFQKS
SQ NGDAEW
XX
SC Swiss-Prot#P52654
XX
FT 1 366 
PF03153; Transcription factor IIA, alpha/beta subunit.
XX
SF this precursor molecule is processed to both alpha (LN) and beta (LC) subunits at a cleavage point around position 225 [2];
SF pI(calc.) = 4.4 (precursor) [2];
SF the alpha moiety (N-terminal part of the precursor) interacts with the gamma subunit [1];
SF weak interaction of TFIIA-beta with TBP [1];
XX
IN T00797 TBP; fruit fly, Drosophila melanogaster.
IN T02226 TFIIA-S; fruit fly, Drosophila melanogaster.
XX
DR TRANSPATH: MO000045977.
DR EMBL: S66759; S66759.
DR UniProtKB: P52654; T2AA_DROME.
DR FLYBASE: FBgn0011289; TfIIA-L.
XX
RN [1]; RE0005665.
RX PUBMED: 7958898.
RA Yokomori K., Zeidler M. P., Chen J.-L., Verrijzer C. P., Mlodzik M.
RT Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation
RL Genes Dev. 8:2313-2323 (1994).
RN [2]; RE0005666.
RX PUBMED: 8224849.
RA Yokomori K., Admon A., Goodrich J. A., Chen J.-L., Tjian R.
RT Drosophila TFIIA-L is processed into two subunits that are associated with the TBP/TAF complex
RL Genes Dev. 7:2235-2245 (1993).
XX
//