AC T02281
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ID T02281
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DT 14.11.1997 (created); ili.
DT 20.04.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA AML3
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SY Acute myelogenous leukemia 3; Acute myeloid leukemia 3 protein; AML3; CBF-alpha 1; CBFA1; Core binding factor A1; Core-binding factor, alpha 1 subunit; Osf2; PEBP2alphaA; PEBP2alphaA1; Polyomavirus enhancer binding protein 2 alpha A subunit; Polyomavirus enhancer binding protein 2alphaA; Runt-related transcription factor 2; RUNX2; RUNX2, PEBP2alphaA, CBFA1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005051 RUNX2; HGNC: RUNX2.
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CL C0029; runt; 6.4.1.0.1.
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SF factor was found to be associated with the nuclear matrix [2];
SF 2 splice variants AML3a T03983 and AML3b T03984;
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CP Cell line SAOS-2 [5].
CN Cell line MG-63 [5].
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FF Runx2 (/AML3)drives mesenchymal stem cells to differentiate into osteoblasts [4];
FF related to human cleidocranial dysplasia (CCD) [1];
FF mapped to chromosome region 6p21 [1];
FF essential for skeletal morphogenesis [1];
FF controls the pathway of differentiation into the osteoblast lineage [3];
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IN T15118 CBP; Mammalia.
IN T02900 UBF; human, Homo sapiens.
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MX M07276 V$AML3_Q3.
MX M01856 V$AML3_Q6.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00731 V$OSF2_Q6.
MX M00984 V$PEBP_Q6.
MX M04108 V$RUNX2_03.
MX M07124 V$RUNX2_04.
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BS R24058.
BS R56276.
BS R56277.
BS R24654.
BS R28442.
BS R66125.
BS R65879.
BS R65880.
BS R64735.
BS R40382.
BS R21196.
BS R26600.
BS R26602.
BS R26603.
BS R05031.
BS R21160.
BS R62557.
BS R62560.
BS R62561.
BS R24485.
BS R29446.
BS R21536.
BS R27635.
BS R31710.
BS R36126.
BS R62906.
BS R67261.
BS R67263.
BS R19529.
BS R38322.
BS R38323.
BS R34786.
BS R20435.
BS R34780.
BS R34782.
BS R34783.
BS R19718.
BS R20209.
BS R71326.
BS R22271.
BS R22273.
BS R24512.
BS R56072.
BS R24722.
BS R19740.
BS R73963.
BS R30361.
BS R04644.
BS R27666.
BS R34778.
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DR TRANSPATH: MO000026285.
DR TRANSCOMPEL: C00196.
DR EMBL: AF001450; RUNX2_HUMAN.
DR UniProtKB: Q13950; RUNX2_HUMAN.
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RN [1]; RE0005889.
RX PUBMED: 9182765.
RA Mundlos S., Otto F., Mundlos C., Mulliken J. B., Aylsworth A. S., Albright S., Lindhout D., Cole W. G., Henn W., Knoll J. H. M., Owen M. J., Mertelsmann R., Zabel B. U., Olsen B. R.
RT Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
RL Cell 89:773-779 (1997).
RN [2]; RE0006488.
RX PUBMED: 9192636.
RA Zeng C., van Wijnen A. J., Stein J. L., Meyers S., Sun W., Shopland L., Lawrence J. B., Penman S., Lian J.B., Stein G. S., Hiebert S. W.
RT Identification of a nuclear matrix targeting signal in leukemia and bone-related AML/CBF-alpha transcription factors
RL Proc. Natl. Acad. Sci. USA 94:6746-6751 (1997).
RN [3]; RE0015316.
RX PUBMED: 9651525.
RA Xiao Z. S., Thomas R., Hinson T. K., Quarles L. D.
RT Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor
RL Gene 214:187-197 (1998).
RN [4]; RE0035398.
RX PUBMED: 16099986.
RA Hong J. H., Hwang E. S., McManus M. T., Amsterdam A., Tian Y., Kalmukova R., Mueller E., Benjamin T., Spiegelman B. M., Sharp P. A., Hopkins N., Yaffe M. B.
RT TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
RL Science 309:1074-1078 (2005).
RN [5]; RE0048864.
RX PUBMED: 14739291.
RA Sevetson B., Taylor S., Pan Y.
RT Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST).
RL J. Biol. Chem. 279:13849-13858 (2004).
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