AC T02900
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ID T02900
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DT 14.01.2000 (created); sur.
DT 06.06.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA UBF
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SY hUBF; nucleolar transcription factor hUBF; RNA polymerase I transcription factor; upstream binding factor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G014315 UBTF; HGNC: Ubtf.
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CL C0015; HMG; 4.1.6.1.1.
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SF activation of transcription requires phosphorylation of UBF [2];
SF UBF is a product of a primary response gene transcribed by RNA Pol II [1];
SF Southern blot analysis indicate that UBF is most likely encoded by a single gene [3];
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FF C-terminal domain is essential for binding to SL1;
FF C-terminal region of UBF is heavily phosphorylated;
FF treatment with AP: UBF fails to interact with SL1;
FF additionally AP treatment of UBF sharply decreases its transcriptional activity [4];
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IN T02281 AML3; human, Homo sapiens.
IN T10998 GAS41; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
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DR TRANSPATH: MO000019789.
DR UniProtKB: P17480; UBF1_HUMAN.
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RN [1]; RE0014001.
RX PUBMED: 7876178.
RA Glibetic M., Taylor L., Larson D., Hannan R., Sells B., Rothblum L.
RT The RNA polymerase I transcription factor UBF is the product of a primary response gene
RL J. Biol. Chem. 270:4209-4212 (1995).
RN [2]; RE0014002.
RX PUBMED: 7651819.
RA Voit R., Kuhn A., Sander E. E., Grummt I.
RT Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF
RL Nucleic Acids Res. 23:2593-2599 (1995).
RN [3]; RE0014007.
RX PUBMED: 2330041.
RA Jantzen H.-M., Admon A., Bell S. P., Tjian R.
RT Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins
RL Nature 344:830-836 (1990).
RN [4]; RE0014018.
RX PUBMED: 10082553.
RA Tuan J. C., Zhai W., Comai L.
RT Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation
RL Mol. Cell. Biol. 19:2872-2879 (1999).
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