AC T02318
XX
ID T02318
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DT 10.12.1997 (created); ili.
DT 15.04.2014 (updated); prb.
CO Copyright (C), QIAGEN.
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FA AML3-G1
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SY CBFA1; PEBP2alphaA; til-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005054 Runx2.
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CL C0029; runt.
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SZ 528 AA; 57.4 kDa (cDNA) (calc.), 70 kDa (SDS) [1]
XX
SQ MASNSLFSAVTPCQQSFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQ
SQ QQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAEL
SQ VRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASA
SQ VMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQK
SQ LDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQS
SQ SPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWP
SQ SSLSKKSQAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMS
SQ ATTHYHTYLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSASYQFPMVPGGDRSPSRMVPPC
SQ TTTSNGSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY
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SC translated from EMBL #AF005936
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FT 15 247 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 106 240 
PF00853; Runt domain.
FT 108 236 
PS51062; RUNT.
FT 403 429 
putative nuclear matrix targeting signal [2].
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SF major isoform (G1) of PEBP2alphaA expressed in murine lymphoma with proviral insertion at til-1locus [1];
SF minor products generated by differential splicing [1];
SF minor products are T02319 and T02320;
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CP osteosarcoma, lymphoma and osteoblast cell lines [1].
CN T cell and fibroblast [1].
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FF identified as a common retroviral integration site in virus-accelerated lymphomas of CD2-myc mice [1];
FF viral insertions appear to activate a promoter that is normally silent in T cells but active in bone [1];
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IN T02936 FOXO1A; human, Homo sapiens.
XX
MX M07276 V$AML3_Q3.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00731 V$OSF2_Q6.
MX M00984 V$PEBP_Q6.
XX
DR TRANSPATH: MO000026315.
DR EMBL: AF005936;
DR UniProtKB: Q08775-5; RUNX2_MOUSE.
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RN [1]; RE0006487.
RX PUBMED: 9238031.
RA Stewart M., Terry A., Hu M., O'Hara M., Blyth K., Baxter E., Cameron E., Onions D. E., Neil J. C.
RT Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): Evidence for a new myc collaborating oncogene
RL Proc. Natl. Acad. Sci. USA 94:8646-8651 (1997).
RN [2]; RE0006488.
RX PUBMED: 9192636.
RA Zeng C., van Wijnen A. J., Stein J. L., Meyers S., Sun W., Shopland L., Lawrence J. B., Penman S., Lian J.B., Stein G. S., Hiebert S. W.
RT Identification of a nuclear matrix targeting signal in leukemia and bone-related AML/CBF-alpha transcription factors
RL Proc. Natl. Acad. Sci. USA 94:6746-6751 (1997).
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//