AC T02332
XX
ID T02332
XX
DT 21.01.1998 (created); ili.
CO Copyright (C), QIAGEN.
XX
FA Shn
XX
SY schnurri; Shn.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
CL C0001; CH.
XX
SZ 2578 AA; 277.6 kDa (cDNA) (calc.).
XX
SQ MYQLALLFKLNYAKHIELISVFSLPLPLSSRFGIDEPTANTSQDNKFDNNMENATITTAK
SQ HYKTAGKQYKTNKVNNTRRATAAAAAAAAAAATTTVTTAATPTKKRTYRETATATTVTQR
SQ STNKANIAAAIALAAATEATASASASATATATDATLTASKAAATAAATTDAASGNSNSSS
SQ KPSTSTRDKLGEVPLPTVDSNHIISNNNNNNNNNNTSNNNNNNHHSDNSISENNYEFKSR
SQ DKASLSDSKMTLQQMAAVSSNQEPVAPNVANTMSNSSIINSQQTTVNATPATDEAPLGDR
SQ SNISRYLHKKFKRLASTTEVDSWSATNGGGALQASGDAVRTTSLSSNSSLSPPPTTPLAN
SQ GHHLMTQQQSHQQVQQQQQQQTPPPSVAIHEFSANFVNSNHVNAIGHEESIISNSGYKAA
SQ GRTRTPLANSNSNTNSTSNSNSNHAANATLSPASFAQHQQLTQPTTVSPGIPGGAAAPNP
SQ ACEKSGRYVCQYQNLICAKPSVLEKHIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSH
SQ AARARGLEVPADADDGLSDQDAELSNSSSELPSRAGSPYEEPINSPTPSPSTLSAAKSAY
SQ IQQPPLPTYMQQLPLGSPAAGTLPPTTADNHHSATAQHRQSIDYKPYKPKFHNASLYSCS
SQ SKELQQQQQQLQIQQQQQQHQLAQQKLSIQLPLVQQPSLAHPTLSPSTQMKMKHHINSHQ
SQ IQLQLQQQQSLLAQQSLLAAMPPGGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHLAQQ
SQ QQQQQQQQQHPPLVKAPPPMQQPPSLPPQQLVRANSQISSVATAPATPTPAANLSTFASS
SQ SGGKQVNVAKVQEHISKLISQNEAIVENKEILLQKKYPKQLSRSRSFNNANSNNASQHGS
SQ NASRLHANNSHNNTNAQMPERETKVNLAQAIFQKQQHQLQQQQQQQITQQQQQQLEQQNY
SQ YTYIQQQQECQQQQLEPPNGVVKRNAYKPGVVMTTPVKQQQQLPPPPSPLPMQTMQYRQD
SQ PATPVTKIEQPTTAVPVMSAKPKPTLVTVPVSSLSTSSLAPTPTTSTNPTSSSKTAPPPA
SQ QVNNSIIKNLLLNARGLAVRLAKAMMLFIRVLSVQANSAVRRSEAAQQHLLSGCELKCPN
SQ ESSIFAIPLQLDLAESTGTEEPHGQLEESLISGQEGWSQLKTKRSSLVLSRLSAAQTPAR
SQ TSTVTAPTVTASAPAPAVATVTAPSSAPAPQIEALRFVDAPLPSPGPLLGKTPLVDYAQQ
SQ STPRKAQDSVVITKMHEDRQFVIEAQPAKRIKTSDLVVASSSQQPTSFNFSFNNQNSSNS
SQ VPELQSSKEERLRRFTSSGGSMIPISECPDLDNSPKMIRTPLLSGGSFQDVSVKVNNETG
SQ SSSKERKLMALVSGSGLLGVSSGPQHFQFPPINSITAFNPLTLPPMSGGDKTTPVTPIPH
SQ VPGMPGPGSLTPQMPLLPPPPQQLQLPIPSSRGRSPMRKQPSPLLLGGGSGELKALSPFG
SQ GVQNVPSEFSRQPPTPAQRQALQWNSKETPKKAPFNFLRMADNVKTTEPEVRHFNLENVI
SQ SGKQQELPLTPLHVDTPNGNAPEETSPVASASASAKSKFLRPTSLPLKPGTFTPKRHHGI
SQ TPTANTLPLISPETPRPSKSCVQLYLNGHAYTYLGLKCSTKMFYCTVNCPQPSYVAGMHK
SQ LSMYSVWQVCEENQPHPLGFKLKQVMALYDSRQRMLGNGSSTAMAGSGKLSYNLVASQQI
SQ VSSPSTSSTSSAFYQGPLKTPPTVTIAALSEANVAAKANEEVQAKKLETSPSGQPLVGGY
SQ ESHEDYTYIRGRGRGRYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNL
SQ TKHMQSKTHFKKCIELGINPGPMPPDSEFLDVDMDFDQQSSTSAGGRTSSMAGESDSDDY
SQ SDNESESSDTDESKSRQKEHEAARGLLSLSMTPPIPQSVSPYPQLQDTPLPAASPANSIG
SQ SSGSQPKRLVCSFTSPKPPFDYQKQEQYYSNPEESKPKRSVANEESAPMDLTKPRGSILL
SQ ISPSPVSVPAHDLPKSQAQQMHDVIFGTSGNESGFMKTLISVSDKVRISAEMEEQAKHEA
SQ EGEDVQLQTYIKEHALHQAKIKQSQFSRSYLINTLYTAASPVMSSSSTLFTANSRPVMSV
SQ NEVPSIEVHEVKTPEAIESPRSAPEQAPVILAQIAQEENEEPNIAEPHNANLPAAVQQPD
SQ VNEFTGVLGNPTAPPTSSVTATSVSTTTAAPVAPSSTANSTQPAQRTVIVGEDGFKSSTP
SQ TSKIGDLQHVSYGRGVPPAPIAGDARPTCTMCSKTFQRQHQLTLHMNIHYMERKFKCEPC
SQ SISFRTQGHLQKHERSEAHKNKVMMTSTFGVPTTSNPRPFECTDCKIAFRIHGHLAKHLR
SQ SKTHVQKLECLQKLPFGTYAEIERAGISLTEIDTSDCENSLISLKLLAQKLQEKDPGKLS
SQ SYTTPSGMMQLAQDAAGPVSQDSASEDGFSAAIASAIASLDNDSAGNTPKRASSMSEDET
SQ VANGLNHSLKRRLPGSFSSTGEESDNPPESSGEKRARSGQELPLPVAVPVAASAAASN
XX
SC Pir #56922
XX
FT 91 1792 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 250 250 
putative alternative start site [1].
FT 488 510 
SM00355; c2h2final6.
FT 488 515 
PS50157; ZINC_FINGER_C2H2_2.
FT 490 510 
zinc finger-like motif [3].
FT 513 547 
SM00451; ZnF_U1_5.
FT 516 540 
PF00096; zf-C2H2.
FT 516 540 
SM00355; c2h2final6.
FT 516 545 
PS50157; ZINC_FINGER_C2H2_2.
FT 664 673 
PF00904; Involucrin repeat.
FT 948 957 PF00904; Involucrin repeat.
FT 1817 1839 PF00096; zf-C2H2.
FT 1817 1839 SM00355; c2h2final6.
FT 1817 1844 PS50157; ZINC_FINGER_C2H2_2.
FT 1842 1876 SM00451; ZnF_U1_5.
FT 1845 1869 PF00096; zf-C2H2.
FT 1845 1869 PS50157; ZINC_FINGER_C2H2_2.
FT 1845 1869 SM00355; c2h2final6.
FT 2307 2329 PF00096; zf-C2H2.
FT 2307 2329 SM00355; c2h2final6.
FT 2307 2334 PS50157; ZINC_FINGER_C2H2_2.
FT 2332 2366 SM00451; ZnF_U1_5.
FT 2335 2359 PF00096; zf-C2H2.
FT 2335 2359 SM00355; c2h2final6.
FT 2335 2364 PS50157; ZINC_FINGER_C2H2_2.
FT 2377 2411 SM00451; ZnF_U1_5.
FT 2380 2404 PF00096; zf-C2H2.
FT 2380 2404 SM00355; c2h2final6.
FT 2380 2409 PS50157; ZINC_FINGER_C2H2_2.
XX
SF similarity to human factors MBP-1(1) T00497 and HIV-EP2 T00939 is restricted to the zinc finger regions;
XX
FF may be a transcription factor because of similarity to MBP-1(1) and HIV-EP2 [1] [2];
FF involved in multiple patterning events that require dpp activity [1];
FF might be a target of the dpp signaling pathway and respond to its stimulation by activating or repressing dpp-responsive genes [2];
FF interaction with Mad T04378 in the presence of TkvA (Dpp Type-1 receptor) [4];
FF Shn 1441-1635, preceding the 2nd set of paired zinc finger, is the strong Mad interaction domain (MID), whereas Shn 341-1069 and Shn 1776-2529 are the weak MIDs [4];
XX
BS R10100.
XX
DR TRANSPATH: MO000026329.
DR EMBL: L42311;
DR EMBL: U31368;
DR UniProtKB: Q24107;
DR UniProtKB: Q24605;
DR FLYBASE: FBgn0003396; shn.
XX
RN [1]; RE0006524.
RX PUBMED: 7774017.
RA Arora K., Dai H., Kazuko S. G., Jamal J., O'Connor M. B., Letsou A., Warrior R.
RT The Drosophila schnurri gene acts in the Dpp/TGFbeta signaling pathway and encodes a transcription factor homologous to the human MBP family
RL Cell 81:781-790 (1995).
RN [2]; RE0006525.
RX PUBMED: 7774018.
RA Grieder N. C., Nellen D., Burke R., Basler K., Affolter M.
RT Schnurri is required for Drosophila dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1
RL Cell 81:791-800 (1995).
RN [3]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [4]; RE0016241.
RX PUBMED: 11071761.
RA Dai H., Hogan C., Gopalakrishnan B., Torres-Vazquez J., Nguyen M., Park S., Raftery L. A., Warrior R., Arora K.
RT The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic.
RL Dev. Biol. 227:373-387 (2000).
XX
//