AC T02667
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ID T02667
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DT 24.02.1999 (created); ewi.
DT 20.05.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA Nkx3-2
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SY Bagpipe homeobox homolog 1; BAPX1; Nkx-3.2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002029 Nkx3-2.
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HO Bap (Drosophila) T02665.
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CL C0006; homeo; 3.1.2.16.2.
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SF rostrocaudal gradient of expression, more rostral regions showing greater intensity than more caudally positioned structures [1];
SF skeletal-specific expression resembles Pax-1 T00677 [1];
SF Bapx-1 deficient mice exhibit lethal skeletal dysplasia (abnormal development of vertebral column and some craniofacial bones), asplenia and gastroduodenal malformation [2] [3];
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CP (embryo >8 days:) lateral plate mesoderm, somites, (embryo >9.5 days:) branchial arches, (embryo 10.5-12.5 days:) developing limbs, gut mesentery, (embryo: 12.5-16.5 days:) Meckel's cartilages, lesser omentum, hindgut [1]; embryo: spleen, vertebral column, cranium [4] [1] [4].
EX Meckel's cartilage,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX Meckel's cartilage,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX cartilaginous condensation of axial skeleton,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX cartilaginous condensation of the forelimbs,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX cartilaginous condensation of the hindlimbs,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX digits of forelimb,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX digits of forelimb,,,Theiler Stage 25; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX digits of hindlimb,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX digits of hindlimb,,,Theiler Stage 25; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX first pharyngeal arch,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX first pharyngeal arch,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX first pharyngeal arch,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX first pharyngeal arch,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX first pharyngeal arch,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX forelimb bud,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX gut mesentery,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX gut mesentery,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX gut mesoderm,,,Theiler Stage 13; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lateral plate mesoderm,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lateral plate mesoderm,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lateral plate mesoderm,,,Theiler Stage 13; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lesser omentum,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX mandibular component,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX preclerotome region,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX sclerotome of trunk mesenchyme,,,Theiler Stage 13; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX sclerotome,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX sclerotome,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX second pharyngeal arch,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX splanchnopleure,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX third pharyngeal arch,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
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FF involved in the formation of visceral mesoderm development, evolutionary recently developed role in skeletal patterning [1];
FF involved in sclerotome migration and proliferation, cartilage development [3];
FF essentially required for ventromedial structure of vertebral column and some craniofacial bones, splenogenesis and morphogenesis of gastroduodenal tract [2] [4];
FF loss of this gene is accompanied by the reduction of proliferative activity in sclerotome cells, loss of differentiation of sclerotome cells into chondrocytes, increase in apoptotic cell death in affected tissues and downregulation of some genes including transcription factors: Col10a1, Osteopontin, Col2a1, Col9a2, aggrecan, MFH1 T02445, Fgfr3, Osf2 T02266, Indian hedgehog, Sox9 T01854 [2] [3];
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MX M01181 V$NKX32_01.
MX M01482 V$NKX32_02.
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BS R67718.
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DR TRANSPATH: MO000026643.
DR UniProtKB: P97503;
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RN [1]; RE0013362.
RX PUBMED: 9256352.
RA Tribioli C., Frasch M., Lufkin T.
RT Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton
RL Mech. Dev. 65:145-162 (1997).
RN [2]; RE0015326.
RX PUBMED: 10886375.
RA Akazawa H., Komuro I., Sugitani Y., Yazaki Y., Nagai R., Noda T.
RT Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation
RL Genes Cells 5:499-513 (2000).
RN [3]; RE0015327.
RX PUBMED: 10572046.
RA Tribioli C., Lufkin T.
RT The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen
RL Development 126:5699-5711 (1999).
RN [4]; RE0024315.
RX PUBMED: 10449756.
RA Lettice L. A., Purdie L. A., Carlson G. J., Kilanowski F., Dorin J., Hill R. E.
RT The mouse bagpipe gene controls development of axial skeleton, skull, and spleen.
RL Proc. Natl. Acad. Sci. USA 96:9695-9700 (1999).
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//