AC T02740
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ID T02740
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DT 02.06.1999 (created); mpr.
DT 12.08.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA TR4
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SY hTAK1; NR2C2; nuclear receptor subfamily 2, group C, member 2; TAK1; TR2R1; TR4.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006489 NR2C2; HGNC: NR2C2.
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CL C0002; CC (rec); 2.1.3.4.2.
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SF orphan nuclear receptor, closely related to the TR2 orphan receptor [1];
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CP hippocampus, cerebellum [1].
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IN T09637 ER-alpha; Mammalia.
IN T01334 RXR-beta; human, Homo sapiens.
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MX M04718 V$NR2C2_02.
MX M04781 V$NR2C2_03.
MX M04934 V$NR2C2_04.
MX M07117 V$NR2C2_05.
MX M01776 V$TR4_01.
MX M01725 V$TR4_Q2.
MX M03568 V$TR4_Q2_01.
MX M08906 V$TR4_Q3.
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BS R29349.
BS R72901.
BS R72905.
BS R20401.
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DR TRANSPATH: MO000026715.
DR UniProtKB: P49116;
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RN [1]; RE0009214.
RX PUBMED: 8016112.
RA Chang C., Silva S. Lopes da, Ideta R., Lee Y., Yeh S., Burbach J. P. H.
RT Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily
RL Proc. Natl. Acad. Sci. USA 91:6040-6044 (1994).
RN [2]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [3]; RE0055445.
RX PUBMED: 18617512.
RA Yu Y., Ge N., Xie M., Sun W., Burlingame S., Pass A. K., Nuchtern J. G., Zhang D., Fu S., Schneider M. D., Fan J., Yang J.
RT Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression.
RL J. Biol. Chem. 283:24497-24505 (2008).
RN [4]; RE0068876.
RX PUBMED: 19687304.
RA Nishimura M., Shin M. S., Singhirunnusorn P., Suzuki S., Kawanishi M., Koizumi K., Saiki I., Sakurai H.
RT TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
RL Mol. Cell. Biol. 29:5529-5539 (2009).
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