AC T02977
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ID T02977
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DT 22.02.2000 (created); sur.
DT 30.06.2004 (updated); spi.
CO Copyright (C), QIAGEN.
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FA armadillo
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SY 86E4.6; Arm; Armadillo segment polarity protein; EG:86E4.6.
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OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
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HO beta-catenin.
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SZ 843 AA; 91.1 kDa (cDNA) (calc.).
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SQ MSYMPAQNRTMSHNNQYNPPDLPPMVSAKEQTLMWQQNSYLGDSGIHSGAVTQVPSLSGK
SQ EDEEMEGDPLMFDLDTGFPQNFTQDQVDDMNQQLSQTRSQRVRAAMFPETLEEGIEIPST
SQ QFDPQQPTAVQRLSEPSQMLKHAVVNLINYQDDAELATRAIPELIKLLNDEDQVVVSQAA
SQ MMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHRQGLLAIF
SQ KSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNNVK
SQ FLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSS
SQ NKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKVEGLEALLQSLVQVLGST
SQ DVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEITEPAVCALRHLT
SQ SRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLIRNLALCPANHAPLREHGA
SQ IHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARESHNR
SQ ALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGPLTDLLHSR
SQ NEGVATYAAAVLFRMSEDKPQDYKKRLSIELTNSLLREDNNIWANADLGMGPDLQDMLGP
SQ EEAYEGLYGQGPPSVHSSHGGRAFHQQGYDTLPIDSMQGLEISSPVGGGGAGGAPGNGGA
SQ VGGASGGGGNIGAIPPSGAPTSPYSMDMDVGEIDAGALNFDLDAMPTPPNDNNNLAAWYD
SQ TDC
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SC PIR #T12689
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FT 44 322 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 149 188 
SM00185; arm_5.
FT 159 200 
armadillo repeat 1 [1].
FT 159 199 
PS50176; ARM_REPEAT.
FT 189 231 
PF00514; Armadillo/beta-catenin-like repeat.
FT 189 231 
SM00185; arm_5.
FT 201 242 
armadillo repeat 2 [1].
FT 201 244 
PS50176; ARM_REPEAT.
FT 232 272 
PF00514; Armadillo/beta-catenin-like repeat.
FT 232 272 
SM00185; arm_5.
FT 243 284 armadillo repeat 3 [1].
FT 243 285 PS50176; ARM_REPEAT.
FT 273 314 SM00185; arm_5.
FT 285 326 armadillo repeat 4 [1].
FT 285 327 PS50176; ARM_REPEAT.
FT 316 357 SM00185; arm_5.
FT 327 368 armadillo repeat 5 [1].
FT 327 370 PS50176; ARM_REPEAT.
FT 358 398 PF00514; Armadillo/beta-catenin-like repeat.
FT 358 398 SM00185; arm_5.
FT 369 410 armadillo repeat 6 [1].
FT 402 437 PF00514; Armadillo/beta-catenin-like repeat.
FT 402 437 SM00185; arm_5.
FT 408 450 PS50176; ARM_REPEAT.
FT 411 449 armadillo repeat 7 [1].
FT 438 481 SM00185; arm_5.
FT 439 481 PF00514; Armadillo/beta-catenin-like repeat.
FT 450 496 armadillo repeat 8 [1].
FT 450 483 PS50176; ARM_REPEAT.
FT 485 527 SM00185; arm_5.
FT 497 538 armadillo repeat 9 [1].
FT 497 540 PS50176; ARM_REPEAT.
FT 528 595 SM00185; arm_5.
FT 539 584 armadillo repeat 10 [1].
FT 585 608 1/2 armadillo repeat 11 [1].
FT 596 636 PF00514; Armadillo/beta-catenin-like repeat.
FT 596 636 SM00185; arm_5.
FT 607 649 PS50176; ARM_REPEAT.
FT 609 647 armadillo repeat 12 [1].
FT 637 677 PF00514; Armadillo/beta-catenin-like repeat.
FT 637 677 SM00185; arm_5.
FT 648 689 armadillo repeat 13 [1].
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SF belongs to the beta-catenin family;
SF 6 exons, 2 classes of mRNA differing in exon 1 encoding the same protein;
SF loss of arm function produces anterior-type denticles in the posterior naked cuticle region of each segment;
SF most armadillo repeats are 42 aa long and a consensus sequence can be formed at 25 of the 42 positions;
SF each repeat consists of a series of four short, structured, hydrophobic regions separated by four polar turn regions [1];
SF armadillo repeats are also found in APC, beta-catenin, plakoglobin (gamma-catenin), importin and other proteins [2];
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CP present in virtually all of the cell types contained in embryo, third-instar larvae and adult ovaries [1].
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FF may be involved in transmitting or interpreting patterning information on the inside of the cell;
FF armadillo is needed for pattern formation processes [1];
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IN T00930 LEF-1; mouse, Mus musculus.
IN T02922 TCF-A; fruit fly, Drosophila melanogaster.
IN T02924 TCF-B; fruit fly, Drosophila melanogaster.
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DR TRANSPATH: MO000026928.
DR EMBL: X54468;
DR UniProtKB: P18824;
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RN [1]; RE0014173.
RX PUBMED: 2707602.
RA Riggleman B., Wieschaus E., Schedl P.
RT Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene
RL Genes Dev. 3:96-113 (1989).
RN [2]; RE0014350.
RX PUBMED: 7907279.
RA Peifer M., Berg S., Reynolds A. B.
RT A repeating amino acid motif shared by proteins with diverse cellular roles
RL Cell 76:789-791 (1994).
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