AC T03481
XX
ID T03481
XX
DT 22.06.2000 (created); hom.
DT 29.11.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Skn7p
XX
SY BRY1; POS9; SKN7; SKN7p; YHR206W.
XX
OS yeast, Saccharomyces cerevisiae
OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
XX
GE G004329 SKN7.
XX
SZ 622 AA; 69.2 kDa (gene) (calc.).
XX
SQ MSFSTINSNVNKTTGDSNNNTTENSSTADLLGMDLLQSGPRLMNTMQPNNSSDMLHINNK
SQ TNNVQQPAGNTNISSANAGAKAPANEFVRKLFRILENNEYPDIVTWTENGKSFVVLDTGK
SQ FTTHILPNHFKHSNFASFVRQLNKYDFHKVKRSPEERQRCKYGEQSWEFQHPEFRVHYGK
SQ GLDNIKRKIPAQRKVLLDESQKALLHFNSEGTNPNNPSGSLLNESTTELLLSNTVSKDAF
SQ GNLRRRVDKLQKELDMSKMESYATKVELQKLNSKYNTVIESLITFKTINENLLNNFNTLC
SQ STLANNGIEVPIFGDNGNRNPTGNTNPATTTAIQSNNNTNNASPATSTVSLQLPNLPDQN
SQ SLTPNAQNNTVTLRKGFHVLLVEDDAVSIQLCSKFLRKYGCTVQVVSDGLSAISTLEKYR
SQ YDLVLMDIVMPNLDGATATSIVRSFDNETPIIAMTGNIMNQDLITYLQHGMNDILAKPFT
SQ RDDLHSILIRYLKDRIPLCEQQLPPRNSSPQTHSNTNTANSNPNTINEQSLAMLPQDNPS
SQ TTTPVTPGASISSAQHVQQGQQEQQHQIFHAQQQQQHHNAIANARSDVAIPNLEHEINTV
SQ PHSSMGSTPQLPQSTLQENQLS
XX
SC Swiss-Prot#P38889
XX
FT 83 188 
SM00415; HSF.
FT 83 283 
PF00447; HSF-type DNA-binding.
FT 87 154 
PS50140; HSF_ETS.
FT 188 579 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 377 488 
SM00448; REC.
FT 377 496 
PF00072; Response regulator receiver domain.
FT 378 492 
PS50110; RESPONSE_REGULATORY.
XX
SF Skn7p contains a potential receiver domain homologous to bacterial response regulator proteins [1];
SF highly conserved aspartic acid residue 427 within this domain is essential for Skn7p function [1];
XX
FF activity of transcription factor is regulated by phosphorylation of a conserved aspartyl residue in the receiver domain. [4];
FF Skn7p and Mbp1p T03480 seem to form a transcription factor independent of G1-S transcription factor MBF [2];
FF high copy Skn7p stimulates the expression of CLN1 and CLN2 [1];
FF in the case of CLN2, stimulation occurs through the MCB/SCB promoter elements [1];
FF modulates CDRE-dependent transcription by influencing Crz1p T03231 levels [3];
XX
IN T00385 Hsf1p; yeast, Saccharomyces cerevisiae.
XX
MX M01535 F$SKN7_01.
MX M01638 F$SKN7_02.
XX
BS R22468.
BS R22471.
BS R22713.
BS R22749.
BS R30983.
BS R22340.
BS R22760.
BS R22762.
BS R23666.
XX
DR EMBL: U00029;
DR EMBL: U00485;
DR EMBL: X83031;
DR UniProtKB: P38889;
XX
RN [1]; RE0011179.
RX PUBMED: 8521825.
RA Morgan B. A., Bouquin N., Merrill G. F., Johnston L. H.
RT A yeast transcription factor bypassing the requirement for SBF and DSC1/MBF in budding yeast has homology to bacterial signal transduction proteins
RL EMBO J. 14:5679-5689 (1995).
RN [2]; RE0014665.
RX PUBMED: 10512874.
RA Bouquin N., Johnson A. L., Morgan B. A., Johnston L. H.
RT Association of the cell cycle transcription factor Mbp1 with the Skn7 response regulator in budding yeast
RL Mol. Biol. Cell 10:3389-3400 (1999).
RN [3]; RE0017744.
RX PUBMED: 11432834.
RA Williams K. E., Cyert M. S.
RT The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p.
RL EMBO J. 20:3473-3483 (2001).
RN [4]; RE0051393.
RX PUBMED: 11854400.
RA Li S., Dean S., Li Z., Horecka J., Deschenes R. J., Fassler J. S.
RT The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p.
RL Mol. Biol. Cell 13:412-424 (2002).
XX
//