AC T04021
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ID T04021
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DT 23.11.2000 (created); rio.
CO Copyright (C), QIAGEN.
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FA Gbx2
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SY gastrulation and brain specific homeobox protein 2.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G002049 Gbx-2.
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CL C0006; homeo.
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SZ 340 AA; 35.9 kDa (cDNA) (calc.).
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SQ MSAAFQPSLMMMQRPLGSSTAFSIDSLIGSPPPPAPGHFVYTGYPMFMPYRPVVLPPPPP
SQ ALPQAALQPPLPPAPPPPLPALPGAFCPGLAQGMALTSTLMAALPGSFPASPPRPEAARK
SQ FAPPGNFDKADGLPPPDGGGGGGDDGKTGGGLLPFPAADAVHASLAGALRGGPKDDPKAE
SQ EEAKGREENFSMDSDLDYSSDENGPAPAAPREEDCGTALEENPPSAANAAANAAATGKNR
SQ RRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAG
SQ NASSKAGEPSRNPKIVVPIPVHVSRFAIRSQHQQLEQARP
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SC translated from EMBL #AF022151
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FT 237 297 
PS50071; HOMEOBOX_2.
FT 239 301 
SM00389; HOX_1.
FT 240 296 
PF00046; Homeobox domain.
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SF three isoforms of 45, 43 and 38 kDa detected in Western blot and South-Western blot assays [1];
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CP (13 days after hatching:) high expression in brain and bursa, low expression in bone marrow, liver, spleen, thymus, (cell lines:) hematopoietic cell lines [1].
CN (13 days after hatching:) gut, kidney, lung, skeletal muscle [1].
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FF target of v-Myb T00895, induction by c-Myb T00139 requires an activated tyrosine kinase pathway origination at the cell surface [1];
FF ectopic expression in myeloblasts mediates monocytic differentiation and growth factor independence [1];
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BS R09587.
BS R09588.
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DR TRANSPATH: MO000027930.
DR EMBL: AF022151;
DR UniProtKB: O42230;
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RN [1]; RE0015348.
RX PUBMED: 9346236.
RA Kowenz-Leutz E., Herr P., Niss K., Leutz A.
RT The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation
RL Cell 91:185-195 (1997).
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