AC T04124
XX
ID T04124
XX
DT 18.12.2000 (created); rio.
DT 30.07.2014 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA PBX3a
XX
SY Pbx3a; pre B-cell leukemia transcription factor 3a.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002139 PBX3; HGNC: PBX3.
XX
CL C0006; homeo; 3.1.4.4.3.1.
XX
SZ 434 AA; 47.2 kDa (cDNA) (calc.).
XX
SQ MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDGRKQDIGDILHQIMTITDQS
SQ LDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGV
SQ SGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIRQIYHTELEKYEQACNEFTTH
SQ VMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRR
SQ NFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKF
SQ QEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGD
SQ SYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNANGGWQDATTPSSVTS
SQ PTEGPGSVHSDTSN
XX
SC translated from EMBL #X59841
XX
FT 34 234 
PF03792; PBX domain.
FT 175 426 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 233 296 
PS50071; HOMEOBOX_2.
FT 235 300 
SM00389; HOX_1.
FT 236 295 
PF00046; Homeobox domain.
XX
SF TALE (three amino acid loop extension) homeo domain superclass [2];
SF 84% and 77% similarity to Pbx-1T01481 T02087 and Pbx-2 T04123 [1];
SF Pbx-3a binds as monomer as well as heterodimer and homodimer [3];
XX
EX adrenal gland (right and left),,,fetal; low; RT-PCR; total RNA; [1].
EX adrenal gland (right and left),,,fetal; none; Northern blot; mRNA (poly-A); [1].
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [1].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [1].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [1].
EX brain,,,fetal; low; Northern blot; mRNA (poly-A); [1].
EX brain,,,fetal; very low; RT-PCR; total RNA; [1].
EX gut,,,fetal; medium; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX heart,,,fetal; low; RT-PCR; total RNA; [1].
EX heart,,,fetal; medium; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,fetal; high; RT-PCR; total RNA; [1].
EX kidney (right and left),,,fetal; low; Northern blot; mRNA (poly-A); [1].
EX liver,,,fetal; high; RT-PCR; total RNA; [1].
EX liver,,,fetal; low; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,fetal; high; RT-PCR; total RNA; [1].
EX lung (right and left),,,fetal; low; Northern blot; mRNA (poly-A); [1].
EX ovary (right and left),,,adult; very high; Northern blot; mRNA (poly-A); [1].
EX spleen,,,fetal; medium; Northern blot; mRNA (poly-A); [1].
EX thymus,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX thymus,,,fetal; medium; Northern blot; mRNA (poly-A); [1].
EX tonsil,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX uterus,,,adult; medium; Northern blot; mRNA (poly-A); [1].
XX
MX M00998 V$PBX_Q3.
MX M07304 V$PBX_Q5.
XX
BS R15380.
BS R14734.
BS R14733.
XX
DR TRANSPATH: MO000028027.
DR EMBL: X59841;
DR UniProtKB: P40426-1;
XX
RN [1]; RE0005181.
RX PUBMED: 1682799.
RA Monica K., Saltman D., Nourse J., Galili N., Cleary M. L.
RT PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1
RL Mol. Cell. Biol. 11:6149-6157 (1991).
RN [2]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [3]; RE0024042.
RX PUBMED: 9234726.
RA Neuteboom S. T., Murre C.
RT Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins.
RL Mol. Cell. Biol. 17:4696-4706 (1997).
RN [4]; RE0024570.
RX PUBMED: 8183558.
RA LeBrun D. P., Cleary M. L.
RT Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.
RL Oncogene 9:1641-1647 (1994).
XX
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