AC T04282
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ID T04282
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DT 01.02.2001 (created); rio.
DT 18.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA Irx-2
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SY iroquois-related homeobox factor 2; Irx2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004480 Irx2.
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CL C0006; homeo.
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SZ 474 AA; 49.5 kDa (cDNA) (calc.).
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SQ MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
SQ GFGSPLQYSADAAAAAAAGFPSYVGSPYDTHTTGMTGAISYHPYGSAAYPYQLNDPAYRK
SQ NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT
SQ WAPRNKSEDEDEDEGDASRSKEESSDKAQDGTETSAEDEGISLHVDSLTDHSCSAESDGE
SQ KLPCRAGDALCESGSECKDKFEDLEDEEDEEDECERDLAPPKPVTSSPLTGVEAPLLSPA
SQ PEAAPRGGSGGKTPLGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAA
SQ AAPASTGAPPGGSPYSASPLLGRHLYYTSPFYGNYTNYGNLNAALQGQGLLRYNTAASSP
SQ GETLHAMPKAASDTGKAGSHSLESHYRPPGGGYEPKKDTSEGCAVVGAGVQTYL
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SC translated from EMBL #AF295369
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FT 113 176 
PS50071; HOMEOBOX_2.
FT 115 180 
SM00389; HOX_1.
FT 116 175 
PF00046; Homeobox domain.
FT 325 342 
SM00548; IRO.
FT 329 340 
IRO box [2].
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SF TALE (three amino acid loop extension) homeo domain superclass [1];
SF homeo domain is identical to human IRX2a T02436 and Irx-5 T04283 of mouse [2];
SF Irx-1 T04281 and Irx-2 have similar expression patterns but Irx-2 is exclusively expressed in the follicles of wiskers [2];
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EX atrioventricular bundle trunk,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX interventricular septum,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX interventricular septum,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX interventricular septum,,,Theiler Stage 24; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX interventricular septum,,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX interventricular septum,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lung,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX trabeculae carneae,cardiac myocyte,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
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FF role in specification of septum and components of the ventricular conduction system [2];
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MX M01405 V$IRX2_01.
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DR TRANSPATH: MO000028146.
DR EMBL: AF295369;
DR UniProtKB: P81066;
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0015698.
RX PUBMED: 10926765.
RA Christoffels V. M., Keijser A. G., Houweling A. C., Clout D. E., Moorman A. F.
RT Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart
RL Dev. Biol. 224:263-274 (2000).
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