AC T04312
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ID T04312
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DT 08.02.2001 (created); rio.
DT 20.08.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA NURR1-isoform1
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SY HZF-3; NR4A2; Nur-related factor 1; Nurr1; RNR-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002230 Nr4a2.
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CL C0002; CC (rec).
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SZ 598 AA; 66.6 kDa (cDNA) (calc.).
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SQ MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSF
SQ STFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSV
SQ YYKPSSPPTPSTPSFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQ
SQ SPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHA
SQ SQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCL
SQ ANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSP
SQ PVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGW
SQ AEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFG
SQ EWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVT
SQ FNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
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SC translated from EMBL #S53744
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FT 26 406 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 260 331 
SM00399; c4gold.
FT 260 335 
PS51030; NUCLEAR_REC_DBD_2.
FT 261 336 
PF00105; Zinc finger, C4 type (two domains).
FT 408 566 
SM00430; holi.
FT 411 591 
PF00104; Ligand-binding domain of nuclear hormon.
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SF Nr4a2 -/- mice fail to generate midbrain dopaminergic neurons, display hyperactivity and movement disturbances and die 1-2 days after birth (probably because of inability to suckle) [3];
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EX compact part of substantia nigra,dopaminergic neuron,,Theiler Stage 17; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX compact part of substantia nigra,dopaminergic neuron,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX ventricular layer of mesencephalic tegmentum,dopaminergic neuron,,Theiler Stage 17; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX ventricular layer of mesencephalic tegmentum,dopaminergic neuron,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
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FF Nurr1 knockout leads to loss of tyrosine hydroxylase (TH) expression in developing midbrain and partial reduction of VIP mRNA. [8];
FF activates expression of tyrosine hydroxylase (TH) in dopaminergic neurons [3];
FF transgenic mice lacking this orphan receptor fail to develop mesencephalic dopamine neurons, so gene for human ortholog T02742 is good candidate for neurologic and psychiatric disorders with an involvement of the dopamine neuron system [6];
FF forms together with Ptx3 T04305 a regulatory cascade for development of the mesencephalic dopaminergic system in which factor may act as an upstream activator [2] [3];
FF expression is induced by PTH (parathyroid hormone: a polypeptide of 84 amino acids) in bone cells (primary osteoblasts) in a PKA-dependent manner [7];
FF induction represents a potential cross-talk mechanism between PTH and steroid hormone signaling at the transcription factor level [7];
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MX M01269 V$NURR1_Q3.
MX M07427 V$NURR1_Q3_01.
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BS R20611.
BS R20612.
BS R20495.
BS R20502.
BS R21685.
BS R20667.
BS R22807.
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DR TRANSPATH: MO000028170.
DR EMBL: S53744;
DR UniProtKB: Q06219-1;
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RN [1]; RE0010393.
RX PUBMED: 7705655.
RA Perlmann T., Jansson L.
RT A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
RL Genes Dev. 9:769-782 (1995).
RN [2]; RE0015734.
RX PUBMED: 9371841.
RA Smidt M. P., van Schaick H. S., Lanctot C., Tremblay J. J., Cox J. J., van der Kleij A. A., Wolterink G., Drouin J., Burbach J. P.
RT A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
RL Proc. Natl. Acad. Sci. USA 94:13305-13310 (1997).
RN [3]; RE0015740.
RX PUBMED: 9092472.
RA Zetterstroem R. H., Solomin L., Jansson L., Hoffer B. J., Olson L., Perlmann T.
RT Dopamine neuron agenesis in Nurr1-deficient mice
RL Science 276:248-250 (1997).
RN [4]; RE0015741.
RX PUBMED: 9143501.
RA Castillo S. O., Xiao Q., Lyu M. S., Kozak C. A., Nikodem V. M.
RT Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene
RL Genomics 41:250-257 (1997).
RN [5]; RE0015742.
RX PUBMED: 7758108.
RA Forman B. M., Umesono K., Chen J., Evans R. M.
RT Unique response pathways are established by allosteric interactions among nuclear hormone receptors
RL Cell 81:541-550 (1995).
RN [6]; RE0016856.
RX PUBMED: 11121187.
RA Buervenich S., Carmine A., Arvidsson M., Xiang F., Zhang Z., Sydow O., Jonsson E. G., Sedvall G. C., Leonard S., Ross R. G., Freedman R., Chowdari K. V., Nimgaonkar V. L., Perlmann T., Anvret M., Olson L.
RT NURR1 mutations in cases of schizophrenia and manic-depressive disorder
RL Am. J. Med. Genet. 96:808-813 (2000).
RN [7]; RE0016863.
RX PUBMED: 11159837.
RA Tetradis S., Bezouglaia O., Tsingotjidou A.
RT Parathyroid hormone induces expression of the nuclear orphan receptor Nurr1 in bone cells
RL Endocrinology 142:663-670 (2001).
RN [8]; RE0050454.
RX PUBMED: 16999955.
RA Luo Y., Henricksen L. A., Giuliano R. E., Prifti L., Callahan L. M., Federoff H. J.
RT VIP is a transcriptional target of Nurr1 in dopaminergic cells.
RL Exp. Neurol. 203:221-232 (2007).
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//