TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02742 XX ID T02742 XX DT 02.06.1999 (created); mpr. DT 05.10.2015 (updated); sup. CO Copyright (C), QIAGEN. XX FA NURR1 XX SY NOT; NR4A2; Nur-related factor 1; Nurr1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002229 NR4A2; HGNC: NR4A2. XX CL C0002; CC (rec); XX SF human homolog of the murine NURR1 T04312 and rat RNR-1 and it is closely related to NAK1/TR3 [2]; SF AF-2 domain is functional (transactivation activity) in a cell type specific manner and function is enhanced by adenoviral oncoprotein E1A [4]; SF binds DNA as monomer and but also heterodimerizes with the 9-cis retinoic acid receptor (RXR) [5]; XX CP expressed in nuclei of glomerulosa cells and fasciculata cells [7]; hNPC's cells [8]. CN cells of adrenal capsule, inner medullary cells [7]. XX FF transgenic mice lacking this orphan receptor T04312 fail to develop mesencephalic dopamine neurons, so this gene for this human ortholog is good candidate for neurologic and psychiatric disorders with an involvement of the dopamine neuron system [3]; FF amino acid exchanges (missense mutations) in schizophrenic or manic-depressive patients caused reduction of in vitro transcriptional activity of dimers of about 30-40% [3]; FF mRNA-levels are slightly increased by all-trans- and 9-cis retinoic acid in MCF-7 cell line [6]; XX IN T01345 RXR-alpha; human, Homo sapiens. IN T01334 RXR-beta; human, Homo sapiens. XX MX M02273 V$NR4A2_01. MX M04480 V$NR4A2_04. MX M08956 V$NR4A2_05. MX M01269 V$NURR1_Q3. MX M07427 V$NURR1_Q3_01. XX BS R22811. BS R73653. BS R28373. BS R20495. BS R20502. BS R67661. BS R40274. BS R67623. BS R23081. BS R66598. BS R66600. BS R66601. BS R62855. BS R62856. XX DR TRANSPATH: MO000026717. DR TRANSCOMPEL: C00515. DR UniProtKB: P43354; XX RN [1]; RE0013625. RX PUBMED: 10219237. RA Nuclear Receptors Nomenclature Committee. RT A unified nomenclature system for the nuclear receptor superfamily RL Cell 97:161-163 (1999). RN [2]; RE0013631. RX PUBMED: 7877627. RA Mages H. W., Rilke O., Bravo R., Senger G., Kroczek R. A. RT NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3 RL Mol. Endocrinol. 8:1583-1591 (1994). RN [3]; RE0016856. RX PUBMED: 11121187. RA Buervenich S., Carmine A., Arvidsson M., Xiang F., Zhang Z., Sydow O., Jonsson E. G., Sedvall G. C., Leonard S., Ross R. G., Freedman R., Chowdari K. V., Nimgaonkar V. L., Perlmann T., Anvret M., Olson L. RT NURR1 mutations in cases of schizophrenia and manic-depressive disorder RL Am. J. Med. Genet. 96:808-813 (2000). RN [4]; RE0016859. RX PUBMED: 10601324. RA Castro D. S., Arvidsson M., Bondesson Bolin M., Perlmann T. RT Activity of the Nurr1 carboxyl-terminal domain depends on cell type and integrity of the activation function 2 RL J. Biol. Chem. 274:37483-37490 (1999). RN [5]; RE0016863. RX PUBMED: 11159837. RA Tetradis S., Bezouglaia O., Tsingotjidou A. RT Parathyroid hormone induces expression of the nuclear orphan receptor Nurr1 in bone cells RL Endocrinology 142:663-670 (2001). RN [6]; RE0016872. RX PUBMED: 9070291. RA Maruyama K., Tsukada T., Bandoh S., Sasaki K., Ohkura N., Yamaguchi K. RT Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7 RL Biochem. Biophys. Res. Commun. 231:417-420 (1997). RN [7]; RE0041790. RX PUBMED: 14645496. RA Bassett M. H., Suzuki T., Sasano H., White P. C., Rainey W. E. RT The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production RL Mol. Endocrinol. 18:279-90 (2004). RN [8]; RE0051463. RX PUBMED: 16252282. RA Jin H., Romano G., Marshall C., Donaldson A. E., Suon S., Iacovitti L. RT Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems. RL J. Cell. Physiol. 207:49-57 (2006). RN [9]; RE0054989. RX PUBMED: 15604093. RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M. RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. RL Mol. Cell. Proteomics 4:205-213 (2005). XX //