AC T04305
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ID T04305
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DT 07.02.2001 (created); rio.
DT 22.05.2013 (updated); sla.
CO Copyright (C), QIAGEN.
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FA Pitx3
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SY paired-like homeodomain transcription factor 3; Ptx-3; Ptx3.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014433 Pitx3.
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HO unc-30 T03371 (C. elegans).
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CL C0006; homeo; 3.1.3.19.3.
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SF bicoid-related homeo domain with highest homology to Pitx1 T02415T02455 and Pitx2 T02410 T02413 [1];
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CP (E11.5:) ventral surface of mesencephalic flexure, (E12.5-15.5:) dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area, sclerotome, cartilaginous derivates, tongue [1].
CN (E19:) adrenal gland [1].
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FF transcriptional activator [1];
FF may be involved in development and/or maintenance of a subset of dopaminergic neurons and forms together with Nr4a2 T04312 (which may act as an upstream activator) a regulatory cascade for development of the mesencephalic dopaminergic system [1];
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MX M01343 V$PITX3_01.
MX M01735 V$PITX3_Q2.
MX M07057 V$PITX3_Q3.
MX M07392 V$PITX3_Q3_01.
MX M08895 V$PITX_Q4.
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DR TRANSPATH: MO000028163.
DR UniProtKB: P81062;
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RN [1]; RE0015734.
RX PUBMED: 9371841.
RA Smidt M. P., van Schaick H. S., Lanctot C., Tremblay J. J., Cox J. J., van der Kleij A. A., Wolterink G., Drouin J., Burbach J. P.
RT A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
RL Proc. Natl. Acad. Sci. USA 94:13305-13310 (1997).
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