AC T04372
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ID T04372
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DT 07.03.2001 (created); rio.
CO Copyright (C), QIAGEN.
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FA Hand2
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SY dHand; heart- and neural crest derivatives-expressed 2; Th2; Thing2.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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CL C0010; bHLH.
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SZ 216 AA; 24.4 kDa (cDNA) (calc.).
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SQ MSLVGGFPHHPVVHHEGYPLRRRRCRRRRRHPLRPRGEPLLHGWLISSHPEMSPPDYSMA
SQ LSYSPEYANGAPGMDHSHYGGVPPGSGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAE
SQ LRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLPKDDQNGEAEAFKAEIKKTDVKEEKR
SQ KKELNEILKSTVSSSDKKTKGRTGWPQHVWALELKQ
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SC translated from EMBL #U40040
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FT 98 151 
PS50888; HLH.
FT 99 151 
PF00010; Helix-loop-helix DNA-binding domain.
FT 104 156 
SM00353; finulus.
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SF 96% amino acid identity to murine Hand2 T04370 [1];
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CP (stage 8:) lateral plate mesoderm, precardiogenic mesoderm, (stage 9:) cardiac crescent, (stage 10:) cardiac tube, sinus venosus, (stage 14:) whole anterior-posterior lateral plate mesoderm, (stage 16-18:) gradient along anterior posterior axis of limb/wing buds, (stage 19-20:) posterior limb bud, (stage 15-20:) atria, left ventricle, bulbus cordis, truncus arteriosus, branchial arches, (stage 23-25:) proximal-anterior location of leg bud, (stage 26-27:) autopod, tarsus, metatarsus, carpus, metacarpus, (stage 28:) interdigits, (stage 30:) lateral borders of developing digits [2] [1].
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FF Hand2 together with Hand1 T04371 may play redundant roles in regulation of heart development especially cardiac looping [1];
FF expression is dependent on AER (apical ectodermal ridge) signalling like Fgf2 [2];
FF overexpression can produce preaxial polydactyly [2];
FF activates members of the shh (sonic hedgehog) pathway (Gli, Patched) [2];
FF role in anterior-posterior patterning of the limb bud [2];
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MX M01034 V$EBOX_Q6_01.
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DR TRANSPATH: MO000028229.
DR EMBL: U40040;
DR UniProtKB: Q90690;
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RN [1]; RE0006279.
RX PUBMED: 8533092.
RA Srivastava D., Cserjesi P., Olson E. N.
RT A subclass of bHLH proteins required for cardiac morphogenesis
RL Science 270:1995-1999 (1995).
RN [2]; RE0015976.
RX PUBMED: 10769237.
RA Fernandez-Teran M., Piedra M. E., Kathiriya I. S., Srivastava D., Rodriguez-Rey J. C., Ros M. A.
RT Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway
RL Development 127:2133-2142 (2000).
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