AC T04450
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ID T04450
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DT 26.04.2001 (created); mas.
DT 18.10.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA T3R-beta2
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SY NR1A2; Nuclear receptor subfamily 1 group A member 2; T3R-beta; THRB; thyroid hormone receptor-beta; TR; TR-beta.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002740 THRB; HGNC: THRB.
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CL C0002; CC (rec); 2.1.2.2.2.2.
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SZ 476 AA; 54.4 kDa (cDNA) (calc.).
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SQ MNYCMQEIYEVHPAAGSNCYMQSTDYYAYFEDSPGYSGCDAQAVPSNNIYMEQAWAVNQP
SQ YTCSYPGNMFKSKDSDLDMALNQYSQPEYFTEEKPTFSQVQSPSYSQKKGYIPSYLDKDE
SQ LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR
SQ FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV
SQ TEAHVATNAQGSHWKQKPKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVD
SQ FAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVIRGQLKNGG
SQ LGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEH
SQ YINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELLPPLFLEVFED
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SC translated and assemled from EMBL #X74497 (pos. 1-109) and #X04707 (pos. 109-476)
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FT 27 398 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 119 192 
SM00399; c4gold.
FT 119 196 
PS51030; NUCLEAR_REC_DBD_2.
FT 120 197 
PF00105; Zinc finger, C4 type (two domains).
FT 226 255 
nuclear co-repressor T04688 binding domain [2].
FT 289 447 
SM00430; holi.
FT 292 473 
PF00104; Ligand-binding domain of nuclear hormon.
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SF complete protein sequence in SWISSPROT (#P37243) in contrast to EMBL entry, where only a combination of two entries (#X04707, aa 1-121 and #X74497, aa 106-461) yields full sequence: sequence conflict between EMBL and SWISSPROT at pos. 293 (I versus T);
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IN T21552 SRC-1; Mammalia.
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MX M02119 V$T3RBETA_Q6_01.
MX M00963 V$T3R_Q6.
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BS R20637.
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DR TRANSPATH: MO000028300.
DR EMBL: X04707;
DR EMBL: X74497;
DR UniProtKB: P10828-2;
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RN [1]; RE0001829.
RX PUBMED: 2879243.
RA Weinberger C., Thompson C. C., Ong E. S., Lebo R., Gruol D. J., Evans R. M.
RT The c-erb-A gene encodes a thyroid hormone receptor
RL Nature 324:641-646 (1986).
RN [2]; RE0010819.
RX PUBMED: 7566114.
RA Hoerlein A. J., Naeaer A. M., Heinzel T., Torchia J., Gloss B., Kurokawa R., Ryan A., Kamei Y., Soederstroem M., Glass C. K., Rosenfeld M. G.
RT Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
RL Nature 377:397-404 (1995).
RN [3]; RE0025766.
RX PUBMED: 12048199.
RA Lin H. M., Zhao L., Cheng S. Y.
RT Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors.
RL J. Biol. Chem. 277:28733-41 (2002).
RN [4]; RE0068910.
RX PUBMED: 19487700.
RA Privalsky M. L., Lee S., Hahm J. B., Young B. M., Fong R. N., Chan I. H.
RT The p160 coactivator PAS-B motif stabilizes nuclear receptor binding and contributes to isoform-specific regulation by thyroid hormone receptors.
RL J. Biol. Chem. 284:19554-19563 (2009).
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