AC T04454
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ID T04454
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DT 02.05.2001 (created); rhe/rge.
DT 18.05.2012 (updated); mka.
CO Copyright (C), QIAGEN.
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FA GT-1
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SY At1g13450.
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OS thale cress, Arabidopsis thaliana
OC eukaryota; viridiplantae; embryobionta; magnoliophyta; magnoliopsida; dilleniidae; capparales; brassicaceae
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GE G002454 GT-1.
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CL C0046; Trihelix.
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SF highly homologous to the DNA binding protein GT-1a T04284 [1];
SF binds to target DNA as a dimer [1];
SF transient expression of the GT-1::beta-glucuronidase fusion protein in onion cells revealed the presence of a nuclear localization signal(s) within the first 215 amino acids [1];
SF whereas phosphorylation by casein kinase II has no apparent effect on hGT-1 DNA binding, phosphorylation by calcium/calmodulin kinase II (CaMKII) increases the binding activity 10-20-fold [2];
SF amongst the 6 potential phosphorylatable residues (T86, T133, S175, T179, S198 and T278), only T133 and S198 are heavily modified [2];
SF phosphorylation of T133 can account for most of the stimulation of DNA-binding activity by CaMKII, indicating that this residue plays an important role in GT-1/BoxII interaction R01317 [2];
SF GT-1 can interact with and stabilize the TFIIA-TBP-TATA complex [3];
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FF GT-1 may act as a molecular switch modulated by calcium-dependent phosphorylation and dephosphorylation in response to light signals [2];
FF GT-1 may activate transcription through direct inter- action with the transcriptional pre-initiation complex [3];
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IN T04454 GT-1; thale cress, Arabidopsis thaliana.
IN T02229 TFIIA-L; thale cress, Arabidopsis thaliana.
IN T02226 TFIIA-S; fruit fly, Drosophila melanogaster.
IN T00800 txnip; thale cress, Arabidopsis thaliana.
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MX M08123 P$GT1_01.
MX M09451 P$GT1_02.
MX M00635 P$GT1_Q6.
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BS R38847.
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DR UniProtKB: Q9FX53;
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RN [1]; RE0016092.
RX PUBMED: 7866025.
RA Hiratsuka K., Wu X., Fukuzawa H., Chua N. H.
RT Molecular dissection of GT-1 from Arabidopsis
RL Plant Cell 6:1805-1813 (1994).
RN [2]; RE0016093.
RX PUBMED: 10437822.
RA Marechal E., Hiratsuka K., Delgado J., Nairn A., Qin J., Chait B. T., Chua N. H.
RT Modulation of GT-1 DNA-binding activity by calcium-dependent phosphorylation
RL Plant Mol. Biol. 40:373-386 (1999).
RN [3]; RE0017077.
RX PUBMED: 10417717.
RA Le Gourrierec J., Li Y. F., Zhou D. X.
RT Transcriptional activation by Arabidopsis GT-1 may be through interaction with TFIIA-TBP-TATA complex
RL Plant J. 18:663-668 (1999).
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