AC T04467
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ID T04467
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DT 09.05.2001 (created); mas.
DT 15.05.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA LXR-beta
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SY LXR B; LXRB; NER; NR1H2; nuclear orphan receptor LXR-beta; orphan nuclear receptor OR-1; oxysterol receptor LXR-beta; ubiquitously expressed nuclear receptor; UR.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002743 Nr1h2.
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CL C0002; CC (rec); 2.1.2.7.2.
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SF binds to DNA elements as a heterodimer with RXR-alpha, see T05701 [4];
SF does not bind to DNA as a monomer or homodimer [3];
SF AF2 domain is necessary for gene activation in response to oxysterols [1];
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CP peritoneal macrophages [4].
EX liver,,,adult; high; Northern blot; total RNA; [2].
EX white fat,,,adult; high; Northern blot; total RNA; [2].
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FF seems to link fatty acid and cholesterol metabolism via induction of SREBP-1c gene expression G002466 (as a heterodimer with RXR-alpha) [2];
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IN T01345 RXR-alpha; human, Homo sapiens.
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MX M00965 V$DR4_Q2.
MX M00647 V$LXR_Q3.
MX M03795 V$LXR_Q6.
MX M07280 V$NR1NR2_Q3.
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BS R27494.
BS R68825.
BS R59922.
BS R59923.
BS R59924.
BS R42105.
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DR TRANSPATH: MO000028317.
DR UniProtKB: Q60644;
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RN [1]; RE0016118.
RX PUBMED: 11035776.
RA Venkateswaran A., Laffitte B. A., Joseph S. B., Mak P. A., Wilpitz D. C., Edwards P. A., Tontonoz P.
RT Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
RL Proc. Natl. Acad. Sci. USA 97:12097-12102 (2000).
RN [2]; RE0016121.
RX PUBMED: 11287605.
RA Yoshikawa T., Shimano H., Amemiya-Kudo M., Yahagi N., Hasty A. H., Matsuzaka T., Okazaki H., Tamura Y., Iizuka Y., Ohashi K., Osuga J. I., Harada K., Gotoda T., Kimura S., Ishibashi S., Yamada N.
RT Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
RL Mol. Cell. Biol. 21:2991-3000 (2001).
RN [3]; RE0017079.
RX PUBMED: 10187832.
RA Feltkamp D., Wiebel F. F., Alberti S., Gustafsson J. A.
RT Identification of a novel DNA binding site for nuclear orphan receptor OR1
RL J. Biol. Chem. 274:10421-10429 (1999).
RN [4]; RE0023359.
RX PUBMED: 10858438.
RA Costet P., Luo Y., Wang N., Tall A. R.
RT Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.
RL J. Biol. Chem. 275:28240-28245 (2000).
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