AC T05701
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ID T05701
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DT 23.10.2003 (created); oke.
DT 13.02.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA LXR-beta:RXR-alpha
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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CL C0002; CC (rec).
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SF heterodimer, for individual polypeptides see mouse LXR-beta T04467 and mouse RXR-alpha T01331;
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FF activator [4];
FF classical DNA binding element is DR4 [4];
FF as shown by oligoselection, binds to DR1, two direct repeats separated by one adenosine [3];
FF activates genes in response to cholesterol, oxysterols (LXR ligands) and/or 9-cis-RA (RXR-alpha ligand) [2] [4] [5];
FF regulates cholesterol transport [2] [4] [5];
FF regulates cholesterol efflux in macrophages via induction of the ABCA1 gene [1];
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MX M02021 V$LXRBRXRA_Q5.
MX M03809 V$LXRBRXRA_Q5_01.
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BS R14242.
BS R14243.
BS R14244.
BS R14245.
BS R14246.
BS R14247.
BS R14248.
BS R14249.
BS R14250.
BS R14251.
BS R14252.
BS R14253.
BS R14254.
BS R14255.
BS R14256.
BS R14238.
BS R14234.
BS R28002.
BS R28491.
BS R28492.
BS R28493.
BS R28494.
BS R28495.
BS R28496.
BS R28554.
BS R14402.
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DR TRANSPATH: MO000054378.
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RN [1]; RE0016118.
RX PUBMED: 11035776.
RA Venkateswaran A., Laffitte B. A., Joseph S. B., Mak P. A., Wilpitz D. C., Edwards P. A., Tontonoz P.
RT Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
RL Proc. Natl. Acad. Sci. USA 97:12097-12102 (2000).
RN [2]; RE0016119.
RX PUBMED: 10968783.
RA Repa J. J., Turley S. D., Lobaccaro J. A., Medina J., Li L., Lustig K., Shan B., Heyman R. A., Dietschy J. M., Mangelsdorf D. J.
RT Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
RL Science 289:1524-1529 (2000).
RN [3]; RE0017079.
RX PUBMED: 10187832.
RA Feltkamp D., Wiebel F. F., Alberti S., Gustafsson J. A.
RT Identification of a novel DNA binding site for nuclear orphan receptor OR1
RL J. Biol. Chem. 274:10421-10429 (1999).
RN [4]; RE0023359.
RX PUBMED: 10858438.
RA Costet P., Luo Y., Wang N., Tall A. R.
RT Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.
RL J. Biol. Chem. 275:28240-28245 (2000).
RN [5]; RE0023589.
RX PUBMED: 10799558.
RA Venkateswaran A., Repa J. J., Lobaccaro J. M., Bronson A., Mangelsdorf D. J., Edwards P. A.
RT Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols.
RL J. Biol. Chem. 275:14700-14707 (2000).
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