AC T04554
XX
ID T04554
XX
DT 04.07.2001 (created); dkl.
DT 17.09.2009 (updated); jag.
CO Copyright (C), QIAGEN.
XX
FA smad4delta3
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SY SMAD-4 delta 3.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002389 SMAD4; HGNC: SMAD4.
XX
CL C0041; SMAD.
XX
SZ 541 AA; 59.4 kDa (cDNA) (calc.).
XX
SQ MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
SQ ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD
SQ LKCDSVCVNPYHYERVVSPGIDSSMMVKDEYVHDFEGQPSLSTEGHSIQTIQHPPSNRAS
SQ TETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQIASGPQPGQQQN
SQ GFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQ
SQ PPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVH
SQ RTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYP
SQ SAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIG
SQ VDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPL
SQ D
XX
SC translated from EMBL #U44378 and modified acc. to ref. [1]
XX
FT 18 142 
PS51075; MH1.
FT 31 140 
SM00523; dwAneu5.
FT 33 137 
PF03165; MH1 domain.
FT 151 508 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 306 521 
PF03166; MH2 domain.
FT 310 519 
SM00524; DWB.
FT 312 541 
PS51076; MH2.
XX
SF splice variant of Smad4 T04292, exon 3 is missing, while the correct reading frame is maintained [1];
SF analysis of the genomic sequence of Smad4 T04292 reveals that any of the five exons between the end of the MH1 domain (exon 2) and the beginning of the MH2 domain (exon 8) can be deleted while maintaining the correct reading frame, T04555, T04557, T04558, T04559>, T04560 [1];
XX
MX M07368 V$SMAD4_Q4.
MX M00733 V$SMAD4_Q6.
MX M01889 V$SMAD4_Q6_01.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
DR TRANSPATH: MO000028391.
DR EMBL: U44378;
DR UniProtKB: Q13485;
XX
RN [1]; RE0016380.
RX PUBMED: 11074002.
RA Pierreux C. E., Nicolas F. J., Hill C. S.
RT Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.
RL Mol. Cell. Biol. 20:9041-9054 (2000).
XX
//