AC T04558
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ID T04558
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DT 04.07.2001 (created); dkl.
DT 17.09.2009 (updated); jag.
CO Copyright (C), QIAGEN.
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FA smad4delta5-6
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SY SMAD-4 delta 5-6.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002389 SMAD4; HGNC: SMAD4.
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CL C0041; SMAD.
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SZ 473 AA; 51.9 kDa (cDNA) (calc.).
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SQ MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
SQ ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD
SQ LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQ
SQ TIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSPVHNELAFQPPISNHPA
SQ PEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERA
SQ RLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFD
SQ LRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLC
SQ ILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
XX
SC translated from EMBL #U44378 and modified acc. to ref. [1]
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FT 18 142 
PS51075; MH1.
FT 31 140 
SM00523; dwAneu5.
FT 33 137 
PF03165; MH1 domain.
FT 119 440 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 238 453 
PF03166; MH2 domain.
FT 242 451 
SM00524; DWB.
FT 244 473 
PS51076; MH2.
XX
SF splice variant of Smad4 T04292, exons 5 and 6 are missing, while the correct reading frame is maintained [1];
SF analysis of the genomic sequence of Smad4 T04292 reveals that any of the five exons between the end of the MH1 domain (exon 2) and the beginning of the MH2 domain (exon 8) can be deleted while maintaining the correct reading frame, T04554, T04555, T04557, T04559>, T04560 [1];
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MX M07368 V$SMAD4_Q4.
MX M00733 V$SMAD4_Q6.
MX M01889 V$SMAD4_Q6_01.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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DR TRANSPATH: MO000028395.
DR EMBL: U44378;
DR UniProtKB: Q13485;
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RN [1]; RE0016380.
RX PUBMED: 11074002.
RA Pierreux C. E., Nicolas F. J., Hill C. S.
RT Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.
RL Mol. Cell. Biol. 20:9041-9054 (2000).
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//