AC T04560
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ID T04560
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DT 04.07.2001 (created); dkl.
DT 17.09.2009 (updated); jag.
CO Copyright (C), QIAGEN.
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FA smad4delta4-7
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SY SMAD-4 delta 4-7.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002389 SMAD4; HGNC: SMAD4.
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CL C0041; SMAD.
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SZ 385 AA; 42.5 kDa (cDNA) (calc.).
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SQ MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
SQ ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD
SQ LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPEYWCSIAYFEMDVQVGETFKVPSSCPI
SQ VTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAV
SQ FVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAG
SQ NIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEI
SQ HLHRALQLLDEVLHTMPIADPQPLD
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SC translated from EMBL #U44378 and modified acc. to ref. [1]
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FT 8 352 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 18 142 
PS51075; MH1.
FT 31 140 
SM00523; dwAneu5.
FT 33 137 
PF03165; MH1 domain.
FT 150 365 
PF03166; MH2 domain.
FT 154 363 
SM00524; DWB.
FT 156 385 
PS51076; MH2.
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SF splice variant of Smad4 T04292, exons 4, 5, 6 and 7 are missing, while the correct reading frame is maintained [1];
SF analysis of the genomic sequence of Smad4 T04292 reveals that any of the five exons between the end of the MH1 domain (exon 2) and the beginning of the MH2 domain (exon 8) can be deleted while maintaining the correct reading frame, T04554, T04555, T04557, T04558>, T04559 [1];
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FF clearly interacts with Smad2 T04095, therefore Smad4 linker is not required for interaction with activated SMAD-2 and all six alternatively spliced variants have correctly folded MH2 domains [1];
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MX M07368 V$SMAD4_Q4.
MX M00733 V$SMAD4_Q6.
MX M01889 V$SMAD4_Q6_01.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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DR TRANSPATH: MO000028397.
DR EMBL: U44378;
DR UniProtKB: Q13485;
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RN [1]; RE0016380.
RX PUBMED: 11074002.
RA Pierreux C. E., Nicolas F. J., Hill C. S.
RT Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.
RL Mol. Cell. Biol. 20:9041-9054 (2000).
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//