AC T04559
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ID T04559
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DT 04.07.2001 (created); dkl.
DT 17.09.2009 (updated); jag.
CO Copyright (C), QIAGEN.
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FA smad4delta4-6
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SY SMAD-4 delta 4-6.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002389 SMAD4; HGNC: SMAD4.
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CL C0041; SMAD.
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SZ 403 AA; 44.5 kDa (cDNA) (calc.).
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SQ MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
SQ ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD
SQ LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPPVHNELAFQPPISNHPAPEYWCSIAYF
SQ EMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQL
SQ ECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQ
SQ QAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGW
SQ GPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
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SC translated from EMBL #U44378 and modified acc. to ref. [1]
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FT 8 370 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 18 142 
PS51075; MH1.
FT 31 140 
SM00523; dwAneu5.
FT 33 137 
PF03165; MH1 domain.
FT 168 383 
PF03166; MH2 domain.
FT 172 381 
SM00524; DWB.
FT 174 403 
PS51076; MH2.
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SF splice variant of Smad4 T04292, exons 4, 5 and 6 are missing, while the correct reading frame is maintained [1];
SF analysis of the genomic sequence of Smad4 T04292 reveals that any of the five exons between the end of the MH1 domain (exon 2) and the beginning of the MH2 domain (exon 8) can be deleted while maintaining the correct reading frame, T04554, T04555, T04557, T04558>, T04560 [1];
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MX M07368 V$SMAD4_Q4.
MX M00733 V$SMAD4_Q6.
MX M01889 V$SMAD4_Q6_01.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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DR TRANSPATH: MO000028396.
DR EMBL: U44378;
DR UniProtKB: Q13485;
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RN [1]; RE0016380.
RX PUBMED: 11074002.
RA Pierreux C. E., Nicolas F. J., Hill C. S.
RT Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.
RL Mol. Cell. Biol. 20:9041-9054 (2000).
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//