AC T04760
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ID T04760
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DT 12.09.2001 (created); rhe/rge.
DT 31.05.2010 (updated); lcl.
CO Copyright (C), QIAGEN.
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FA NPR1
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SY AT1G64280; F15H21.6; NIM1.
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OS thale cress, Arabidopsis thaliana
OC eukaryota; viridiplantae; embryobionta; magnoliophyta; magnoliopsida; dilleniidae; capparales; brassicaceae
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GE G002691 NPR1.
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SF interacts strongly with TGA2 T02795and TGA6 T02797, but only weakly with OBF5 T02661 through Ankyrin Repeat domain [3];
SF contains three TTGAC W-box sequences within a 28-bp region from 103 to position 129 upstream of translation start site [5];
SF interacts with TGA3 T02796, but weakly with TGA4 T02659 [6];
SF in unstimulated arabidopsis leaves, NPR1 was detected in the cytoplasmic and nuclear fractions [6];
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FF controls systemic acquired resistance [1];
FF NPR1 is required for the DNA binding activity of TGA2 [7];
FF NPR1 mutants lose the ability to interact with TGA2 and TGA3 [6];
FF enhances the binding activity of TGA2 to the as-1 element, to the positive LS7 and negative LS5 regulatory elements [6];
FF interacts strongly with TGA2 T02795 and TGA5 T02661 in vitro [8];
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IN T05497 NIMIN-1; thale cress, Arabidopsis thaliana.
IN T05496 NIMIN-2; thale cress, Arabidopsis thaliana.
IN T05498 NIMIN-3; thale cress, Arabidopsis thaliana.
IN T02659 OBF4; thale cress, Arabidopsis thaliana.
IN T02661 OBF5; thale cress, Arabidopsis thaliana.
IN T02794 TGA1; thale cress, Arabidopsis thaliana.
IN T04757 TGA2.1; tobacco, Nicotiana tabacum.
IN T04758 TGA2.2; tobacco, Nicotiana tabacum.
IN T02795 TGA2; thale cress, Arabidopsis thaliana.
IN T02796 TGA3; thale cress, Arabidopsis thaliana.
IN T02797 TGA6; thale cress, Arabidopsis thaliana.
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DR UniProtKB: P93002;
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RN [1]; RE0016869.
RX PUBMED: 10809449.
RA Niggeweg R., Thurow C., Weigel R., Pfitzner U., Gatz C.
RT Tobacco TGA factors differ with respect to interaction with NPR1, activation potential and DNA-binding properties
RL Plant Mol. Biol. 42:775-788 (2000).
RN [2]; RE0016877.
RX PUBMED: 9019406.
RA Cao H., Glazebrook J., Clarke J. D., Volko S., Dong X.
RT The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats
RL Cell 88:57-63 (1997).
RN [3]; RE0017080.
RX PUBMED: 10339621.
RA Zhang Y., Fan W., Kinkema M., Li X., Dong X.
RT Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene
RL Proc. Natl. Acad. Sci. USA 96:6523-6528 (1999).
RN [4]; RE0022623.
RX PUBMED: 11442055.
RA Weigel R. R., Bauscher C., Pfitzner A. J., Pfitzner U. M.
RT NIMIN-1, NIMIN-2 and NIMIN-3, members of a novel family of proteins from Arabidopsis that interact with NPR1/NIM1, a key regulator of systemic acquired resistance in plants.
RL Plant Mol. Biol. 46:143-160 (2001).
RN [5]; RE0022639.
RX PUBMED: 11449049.
RA Yu D., Chen C., Chen Z.
RT Evidence for an important role of WRKY DNA binding proteins in the regulation of NPR1 gene expression.
RL Plant Cell 13:1527-1540 (2001).
RN [6]; RE0022649.
RX PUBMED: 10662863.
RA Despres C., DeLong C., Glaze S., Liu E., Fobert P. R.
RT The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors.
RL Plant Cell 12:279-290 (2000).
RN [7]; RE0022938.
RX PUBMED: 12084833.
RA Fan W., Dong X.
RT In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis.
RL Plant Cell 14:1377-1389 (2002).
RN [8]; RE0023648.
RX PUBMED: 12383081.
RA Kim H. S., Delaney T. P.
RT Over-expression of TGA5, which encodes a bZIP transcription factor that interacts with NIM1/NPR1, confers SAR-independent resistance in Arabidopsis thaliana to Peronospora parasitica.
RL Plant J. 32:151-163 (2002).
RN [9]; RE0050945.
RX PUBMED: 11489188.
RA Chern M. S., Fitzgerald H. A., Yadav R. C., Canlas P. E., Dong X., Ronald P. C.
RT Evidence for a disease-resistance pathway in rice similar to the NPR1-mediated signaling pathway in Arabidopsis.
RL Plant J. 27:101-113 (2001).
RN [10]; RE0051407.
RX PUBMED: 15805484.
RA Hepworth S. R., Zhang Y., McKim S., Li X., Haughn G. W.
RT BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning in Arabidopsis.
RL Plant Cell 17:1434-1448 (2005).
RN [11]; RE0051707.
RX PUBMED: 12953119.
RA Despres C., Chubak C., Rochon A., Clark R., Bethune T., Desveaux D., Fobert P. R.
RT The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1.
RL Plant Cell 15:2181-2191 (2003).
RN [12]; RE0052725.
RX PUBMED: 15749762.
RA Weigel R. R., Pfitzner U. M., Gatz C.
RT Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis.
RL Plant Cell 17:1279-1291 (2005).
RN [13]; RE0065152.
RX PUBMED: 18700826.
RA Quilis J., Penas G., Messeguer J., Brugidou C., San Segundo B.
RT The Arabidopsis AtNPR1 inversely modulates defense responses against fungal, bacterial, or viral pathogens while conferring hypersensitivity to abiotic stresses in transgenic rice.
RL Mol. Plant Microbe Interact. 21:1215-1231 (2008).
RN [14]; RE0065724.
RX PUBMED: 18635760.
RA Tada Y., Spoel S. H., Pajerowska-Mukhtar K., Mou Z., Song J., Wang C., Zuo J., Dong X.
RT Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins.
RL Science 321:952-956 (2008).
RN [15]; RE0066982.
RX PUBMED: 19490895.
RA Spoel S. H., Mou Z., Tada Y., Spivey N. W., Genschik P., Dong X.
RT Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity.
RL Cell 137:860-872 (2009).
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