AC T04781
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ID T04781
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DT 14.09.2001 (created); mas.
DT 28.04.2009 (updated); pch.
CO Copyright (C), QIAGEN.
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FA PPARdelta
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SY FAAR; fatty acid activated receptor; NR1C2; NUC1; nuclear hormone receptor 1; peroxisome proliferator-activated receptor beta; PPAR-delta; PPARb/d; PPARbeta; PPARdelta.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002770 Ppard.
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CL C0002; CC (rec); 2.1.2.5.2.
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SF at least four different variants result from the alternative promoters upstream of exons 1A, 1B, 1C, 1D and alternative splicing [4];
SF forms heterodimers with RXR-alpha and RXR-beta [1];
SF conflict in protein sequence between EMBL entry #U10375 and SWISSPROT entry #P35396: pos. 149-150 (DG versus EA);
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EX adipose tissue,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX lung,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; low; Northern blot; mRNA (poly-A); [1].
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FF ligands: fatty acids, prostaglandins [1] [6];
FF plays a role during oligodendrocyte proliferation and maturation [3];
FF mediator of fatty acid transcriptional effects in preadipocytes [1];
FF involved in the regulation of lipid metabolism [5];
FF plays a role in adipogenesis by regulation of PPAR-gamma gene expression [6];
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IN T01345 RXR-alpha; human, Homo sapiens.
IN T01334 RXR-beta; human, Homo sapiens.
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MX M00763 V$PPARDR1_Q2.
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BS R27470.
BS R27361.
BS R20237.
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DR TRANSPATH: MO000028591.
DR UniProtKB: P35396;
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RN [1]; RE0011657.
RX PUBMED: 7836471.
RA Amri E. Z., Bonino F., Ailhaud G., Abumrad N. A., Grimaldi P. A.
RT Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors.
RL J. Biol. Chem. 270:2367-2371 (1995).
RN [2]; RE0018164.
RX PUBMED: 11117527.
RA Lazennec G., Canaple L., Saugy D., Wahli W.
RT Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
RL Mol. Endocrinol. 14:1962-1975 (2000).
RN [3]; RE0018251.
RX PUBMED: 11779158.
RA Magge S. S., Guardiola-Diaz H. M.
RT Characterization of the mouse peroxisome proliferator-activated receptor delta gene.
RL Biochem. Biophys. Res. Commun. 290:230-235 (2002).
RN [4]; RE0018252.
RX PUBMED: 12059785.
RA Larsen L. K., Amri E. Z., Mandrup S., Pacot C., Kristiansen K.
RT Genomic organization of the mouse peroxisome proliferator-activated receptor beta/delta gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency.
RL Biochem. J. 366:767-775 (2002).
RN [5]; RE0018256.
RX PUBMED: 10818235.
RA Leibowitz M. D., Fievet C., Hennuyer N., Peinado-Onsurbe J., Duez H., Bergera J., Cullinan C. A., Sparrow C. P., Baffic J., Berger G. D., Santini C., Marquis R. W., Tolman R. L., Smith R. G., Moller D. E., Auwerx J.
RT Activation of PPARdelta alters lipid metabolism in db/db mice.
RL FEBS Lett. 473:333-336 (2000).
RN [6]; RE0018259.
RX PUBMED: 10419513.
RA Bastie C., Holst D., Gaillard D., Jehl-Pietri C., Grimaldi P. A.
RT Expression of peroxisome proliferator-activated receptor PPARdelta promotes induction of PPARgamma and adipocyte differentiation in 3T3C2 fibroblasts.
RL J. Biol. Chem. 274:21920-21925 (1999).
RN [7]; RE0018281.
RX PUBMED: 8041794.
RA Kliewer S. A., Forman B. M., Blumberg B., Ong E. S., Borgmeyer U., Mangelsdorf D. J., Umesono K., Evans R. M.
RT Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
RL Proc. Natl. Acad. Sci. USA 91:7355-7359 (1994).
RN [8]; RE0035800.
RX PUBMED: 10872826.
RA Yi Y. W., Kim D., Jung N., Hong S. S., Lee H. S., Bae I.
RT Gadd45 family proteins are coactivators of nuclear hormone receptors.
RL Biochem. Biophys. Res. Commun. 272:193-198 (2000).
RN [9]; RE0050602.
RX PUBMED: 16943204.
RA Woo C. H., Massett M. P., Shishido T., Itoh S., Ding B., McClain C., Che W., Vulapalli S. R., Yan C., Abe J.
RT ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.
RL J. Biol. Chem. 281:32164-32174 (2006).
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