AC T04813
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ID T04813
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DT 05.10.2001 (created); mas.
DT 04.02.2009 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA FOXP1c
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SY forkhead-related transcription factor 1; FOXP1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002814 Foxp1.
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CL C0023; fork head.
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SZ 455 AA; 50.5 kDa (cDNA) (calc.).
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SQ MIPTELQQLWKEVTSAHTAEETTSSNHSSLDLTSTCVSSSAPSKSSLIMNPHASTNGQLS
SQ VHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCDDFPAFLKHLNSEHALDDRSTAQCR
SQ VQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQS
SQ LPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNA
SQ EVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKC
SQ FVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSI
SQ PLYTTASMGNPTLGSLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPIHVKEEPLDP
SQ EEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME
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SC translated from EMBL #AF339105
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FT 1 1 
N-terminal extension of 250 amino acids in isoforms T04811 and T04812 [2].
FT 86 109 
putative zinc-finger region [2].
FT 111 176 
dimerization domain [3].
FT 126 147 
leucine zipper (VL3) [3].
FT 235 323 
winged-helix/forhead DNA-binding domain [2].
FT 241 322 
SM00339; forkneu4.
FT 243 326 
necessary and sufficient for DNA-binding [1].
FT 243 316 
PS50039; FORK_HEAD_3.
FT 243 337 
PF00250; Fork head domain.
FT 289 352 
missing in isoform T04812 [2].
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SF member of a new subfamily of winged-helix/forkhead DNA binding domain transcription factors [2];
SF 3 isoforms exist that are most probably caused by differential splicing: T04811, T04812, T04813 [2];
SF lacks glutamine-rich region that is present in isoforms T04811 and T04812 [2];
SF existence of drosophila protein with high similarity in forkhead domain [2];
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CP (adult:) (high) lung, (medium) heart, kidney, skeletal muscle, spleen, brain, liver [2]; (high) lung, testis, (medium) heart, kidney, liver, intestine, skeletal muscle, spleen (protein) [3] [2] [3].
EX brain,,,adult; detectable; Northern blot; total RNA; [2].
EX heart,,,adult; detectable; Northern blot; total RNA; [2].
EX kidney (right and left),,,adult; detectable; Northern blot; total RNA; [2].
EX liver,,,adult; detectable; Northern blot; total RNA; [2].
EX lung,,,adult; detectable; Northern blot; total RNA; [2].
EX muscles,,,adult; detectable; Northern blot; total RNA; [2].
EX small intestine,,,adult; none; Northern blot; total RNA; [2].
EX spleen,,,adult; detectable; Northern blot; total RNA; [2].
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IN T04811 FOXP1a; mouse, Mus musculus.
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MX M00987 V$FOXP1_01.
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DR TRANSPATH: MO000028620.
DR EMBL: AF339105;
DR UniProtKB: P58462-3;
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RN [1]; RE0006383.
RX PUBMED: 8265594.
RA Li C., Tucker P. W.
RT DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain
RL Proc. Natl. Acad. Sci. USA 90:11583-11587 (1993).
RN [2]; RE0016948.
RX PUBMED: 11358962.
RA Shu W., Yang H., Zhang L., Lu M. M., Morrisey E. E.
RT Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors
RL J. Biol. Chem. 276:27488-27497 (2001).
RN [3]; RE0024165.
RX PUBMED: 12692134.
RA Wang B., Lin D., Li C., Tucker P.
RT Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors.
RL J. Biol. Chem. 278:24259-24268 (2003).
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