AC T04811
AS T02289.
XX
ID T04811
XX
DT 05.10.2001 (created); mas.
DT 04.02.2009 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA FOXP1a
XX
SY forkhead-related transcription factor 1; FOXP1; glutamine (Q)-rich factor 1; QRF1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002814 Foxp1.
XX
CL C0023; fork head.
XX
SZ 705 AA; 78.8 kDa (cDNA) (calc.).
XX
SQ MMQESGSETKSNGSAIQNGSSGGNHLLECGALRDTRSNGEAPAVDLGAADLAHVQQQQQQ
SQ ALQVARQLLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVSGLKSPKRNDKQ
SQ PALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQLQEFYKKQQ
SQ EQLQLQLLQQQHAGKQPKEQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQP
SQ ALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTSSNHSSLDLTSTCVSSSAPSKSSLIMN
SQ PHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCDDFPAFLKHLNSEHA
SQ LDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLS
SQ KSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADI
SQ AQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNA
SQ VRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAA
SQ LQASMAENSIPLYTTASMGNPTLGSLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHP
SQ IHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME
XX
SC translated from EMBL #AF339103
XX
FT 1 130 
missing in splice variant FOXP1d T05943 [3].
FT 1 250 
missing in splice variant FOXP1c T04813 [2].
FT 55 230 
glutamine-rich region (90/176) [2].
FT 97 433 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 251 490 
transcriptional repressor region (functional) [2].
FT 334 359 
zink finger structure [4].
FT 336 359 
putative zinc-finger region [2].
FT 361 426 
dimerization domain (functional) [3].
FT 376 397 
leucine zipper (VL3) [3].
FT 485 573 
winged-helix/forkhead DNA-binding domain [2].
FT 491 572 SM00339; forkneu4.
FT 493 576 necessary and sufficient for DNA-binding [1].
FT 493 566 PS50039; FORK_HEAD_3.
FT 493 587 PF00250; Fork head domain.
FT 507 516 PF00904; Involucrin repeat.
FT 539 602 missing in splice variant FOXP1b T04812 [2].
XX
SF member of a new subfamily of winged-helix/forkhead DNA binding domain transcription factors [2];
SF 3 isoforms exist that are most probably caused by differential splicing: T04811, T04812, T04813 [2];
SF 62 % identity to ortholog T04814 [2];
SF existence of drosophila protein with high similarity in forkhead domain [2];
SF fork head domain is necessary and sufficient for DNA-binding [1];
SF the "basic hook" at the N-terminus of the fragment, like other parts, is essential for DNA-binding [1];
XX
CP widely expressed (protein), (high:) lung, (medium:) brain, spleen, (low:) heart, liver, large intestine, skeletal muscle, testis [3].
XX
FF repressor of epithelial lung gene transcription, as shown for the mouse CC10 promoter G002818 and the human SP-C promoter G002817 [2];
XX
IN T04811 FOXP1a; mouse, Mus musculus.
IN T04813 FOXP1c; mouse, Mus musculus.
IN T05943 FOXP1d; mouse, Mus musculus.
IN T04280 FOXP3; human, Homo sapiens.
XX
MX M00987 V$FOXP1_01.
XX
BS R14843.
BS R15511.
BS R15512.
BS R15513.
BS R15514.
BS R15515.
BS R15516.
BS R15517.
BS R15518.
BS R15519.
BS R15520.
BS R15521.
BS R15522.
BS R15523.
BS R15524.
BS R15525.
BS R15526.
BS R15527.
BS R15528.
BS R15529.
BS R15530.
BS R15531.
BS R15532.
BS R15533.
BS R15534.
BS R14844.
BS R15535.
BS R15536.
BS R15537.
BS R15538.
BS R15539.
BS R15540.
BS R15541.
BS R15542.
BS R15543.
BS R15544.
BS R15545.
BS R15546.
BS R15547.
BS R15548.
BS R15549.
BS R15550.
BS R15551.
BS R15552.
BS R15553.
BS R15554.
BS R14845.
BS R15555.
BS R15556.
BS R15557.
BS R15558.
BS R15559.
BS R15560.
BS R15561.
BS R15562.
BS R15563.
BS R15564.
BS R15565.
BS R15566.
BS R15567.
BS R15568.
BS R15569.
BS R15570.
BS R15571.
BS R15572.
BS R15573.
BS R15574.
BS R15575.
BS R15576.
BS R15577.
BS R15578.
BS R15579.
BS R14846.
BS R14847.
BS R14848.
BS R14849.
XX
DR TRANSPATH: MO000028618.
DR EMBL: AF339103;
DR UniProtKB: P58462;
XX
RN [1]; RE0006383.
RX PUBMED: 8265594.
RA Li C., Tucker P. W.
RT DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain
RL Proc. Natl. Acad. Sci. USA 90:11583-11587 (1993).
RN [2]; RE0016948.
RX PUBMED: 11358962.
RA Shu W., Yang H., Zhang L., Lu M. M., Morrisey E. E.
RT Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors
RL J. Biol. Chem. 276:27488-27497 (2001).
RN [3]; RE0024165.
RX PUBMED: 12692134.
RA Wang B., Lin D., Li C., Tucker P.
RT Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors.
RL J. Biol. Chem. 278:24259-24268 (2003).
RN [4]; RE0048528.
RX PUBMED: 12818433.
RA Teufel A., Wong E. A., Mukhopadhyay M., Malik N., Westphal H.
RT FoxP4, a novel forkhead transcription factor.
RL Biochim. Biophys. Acta 1627:147-152 (2003).
XX
//