AC T04861
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ID T04861
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DT 12.11.2001 (created); mas.
DT 22.08.2008 (updated); nhb.
CO Copyright (C), QIAGEN.
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FA PNR
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SY NR2E3; photoreceptor-specific nuclear receptor; retina-specific nuclear receptor; RNR.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002889 Nr2e3.
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CL C0002; CC (rec); 2.1.3.3.2.
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SF shows 90% sequence identity to human ortholog T03723 [1];
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EX cerebellum,,,adult; none; Northern blot; total RNA; [2].
EX cerebellum,,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX cerebral cortex,,,adult; none; Northern blot; total RNA; [2].
EX cerebral cortex,,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX heart,,,adult; none; Northern blot; total RNA; [2].
EX heart,,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX inner nuclear layer of retina,M�ller's radial cell of retina,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX inner plexiform layer of retina,M�ller's radial cell of retina,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX kidney (right and left),,,adult; none; Northern blot; total RNA; [2].
EX kidney (right and left),,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX layer of inner and outer segments of retina,,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX liver,,,adult; none; Northern blot; total RNA; [2].
EX liver,,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lung,,,adult; none; Northern blot; total RNA; [2].
EX lung,,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic part of retina,cone cell of retina,,adult; high; Northern blot; total RNA; [2].
EX optic part of retina,cone cell of retina,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX optic part of retina,rod cell of retina,,adult; high; Northern blot; total RNA; [2].
EX optic part of retina,rod cell of retina,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX outer nuclear layer of retina,,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX retinal pigment epithelium,M�ller's radial cell of retina,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX spleen,,,adult; none; Northern blot; total RNA; [2].
EX spleen,,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
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FF potential transcriptional repressor [1];
FF ligand-independent transcriptional repression activity of ligand-binding domain [1];
FF deletion, that eliminates a portion of DNA-binding domain or hinge region (contradiction: different domain assignments) and creating premature stop codon, leads to hereditary retinal dysplasia and degeneration in the rd7 mouse [1] [2];
FF binds to promoter of human CRALBP (cellular retinaldehyde binding protein) gene, but only in the presence of RAR-alpha T00719 or RXR-beta T01332 [1];
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MX M01650 V$PNR_01.
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DR TRANSPATH: MO000028659.
DR UniProtKB: Q9QXZ7;
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RN [1]; RE0017116.
RX PUBMED: 10611353.
RA Chen F., Figueroa D. J., Marmorstein A. D., Zhang Q., Petrukhin K., Caskey C. T., Austin C. P.
RT Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Muller glial cells
RL Proc. Natl. Acad. Sci. USA 96:15149-15154 (1999).
RN [2]; RE0017118.
RX PUBMED: 10805811.
RA Akhmedov N. B., Piriev N. I., Chang B., Rapoport A. L., Hawes N. L., Nishina P. M., Nusinowitz S., Heckenlively J. R., Roderick T. H., Kozak C. A., Danciger M., Davisson M. T., Farber D. B.
RT A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse
RL Proc. Natl. Acad. Sci. USA 97:5551-5556 (2000).
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//