AC T05040
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ID T05040
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DT 26.02.2002 (created); mas.
DT 28.03.2008 (updated); pum.
CO Copyright (C), QIAGEN.
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FA RP58
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SY 58 KDA repressor protein; TAZ-1; transcriptional repressor RP58; translin-associated zinc finger protein-1; ZBTB18; Zinc finger and BTB domain-containing protein 18; zinc finger protein 238; Zinc finger protein C2H2-171.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003023 ZBTB18; HGNC: ZBTB18.
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CL C0001; CH; 2.3.3.16.1.
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SF N-terminal region (called POZ domain, aa 1-115) highly conserved in other members of C2H2-type zinc finger proteins: 30-40% amino acid identity with human BCL-6 T02322, human HIC-1, human PLZF T02336, human KUP T00457, mouse ZF-5 T02349, human ZID [1];
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EX brain,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; very high; Western blot; protein; [1].
EX colon,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; low; Western blot; protein; [1].
EX kidney (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; very low; Western blot; protein; [1].
EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX lymphatic tissue,lymphocyte,,adult; high; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX ovary (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX pancreas,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX placenta,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX prostate gland,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; high; Northern blot; mRNA (poly-A); [1].
EX thymus,,,adult; low; Northern blot; mRNA (poly-A); [1].
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FF repressor (mediates transcriptional repression on sequence with multiple copies of consensus sequence CAGATGTT) [1];
FF interacts with translin, a hotspot binding protein associated with chromosomal translocations [1];
FF subcellular location: associates in cell nucleus with condensed chromatin (probably heterochromatin) [1];
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MX M00532 V$RP58_01.
MX M05428 V$RP58_02.
MX M07465 V$RP58_Q3.
MX M03934 V$ZBTB18_01.
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BS R73099.
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DR TRANSPATH: MO000028789.
DR UniProtKB: Q99592;
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RN [1]; RE0017569.
RX PUBMED: 9756912.
RA Aoki K., Meng G., Suzuki K., Takashi T., Kameoka Y., Nakahara K., Ishida R., Kasai M.
RT RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression.
RL J. Biol. Chem. 273:26698-26704 (1998).
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