AC T05041
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ID T05041
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DT 27.02.2002 (created); mas.
DT 27.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA COL-1
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SY COL; COL isoform 1; COL1; Collier; KN; knot.
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OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
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GE G003030 kn.
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HO COE1 (mouse), Olf-1 (rat).
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CL C0011; HLH.
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SZ 575 AA; 62.5 kDa (calc.).
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SQ MEWGRKLYPSAVSGPRSAGGLMFGLPPTAAVDMNQPRGPMTSLKEEPLGSRWAMQPVVDQ
SQ SNLGIGRAHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKT
SQ NNGIQYRLQLLYANGARQEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRC
SQ CDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVISTQVAVDGP
SQ LLAISDNMFVHNNSKHGRRAKRLDTTEGTGNTSLSISGHPLAPDSTYDGLYPPLPVATPC
SQ IKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGTMLVWSELITSHAIRVQTPPSDIPGVV
SQ EVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRLQKLIPRHPGDPEKLQKEIILKRA
SQ ADLVEALYSMPRSPDGSTGFNSYAGQLAVSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSS
SQ ASTPHSSGGSYGATAASAAVAATANGYAPAPNMGTLSSSPGSVFNSTSMSAVSSTWHQAF
SQ VQHHHAATAHPHHHYPHPHQPWHNPAVSAATAAAV
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SC translated from EMBL #X97803
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FT 59 288 
DNA-binding domain [2].
FT 289 429 
dimerization domain [2].
FT 298 382 
SM00429; iptmega2.
FT 299 382 
PF01833; IPT/TIG domain.
FT 413 431 
type-2 HLH-related helix [1].
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SF existence of two isoforms COL1 T05041 and COL2 T05055 due to alternative splicing (3.9 and 3.4 kb) [3];
SF absence of the first type-2 helix of the HLH-related motif which is found in mouse homologs T01112, T05006 [1];
SF DNA-binding domain shows 85 % and 86 % amino acid identity to that of mouse homologs T05041 and T01112 [1] [3];
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CP (embryo:) detectable from 3 h AEL onwards, peak between 8 and 16 h AEL [3]; in stage 13 and 14 embryos expressed in a segmentally reiterated pattern in the ventral nerve cord and peripheral nervous system [3]; expressed in posterior cells of intercalary segment and anterior cells of mandibular segment (parasegment 0) [2] [3]; expressed during early gastrulation in mitotic domain 2 cells which enter mitosis synchronously [3]; (larvae, pupa:) low levels in L1, higher levels in L3, pupa [3] [2] [3].
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FF required for normal embryonic head morphogenesis (second-level regulator in head patterning): reduction of its activity results in specific lack of head structures [2] [3];
FF expression controlled by gap genes of the head [3];
FF required for intercalary-segment expression both of the segment polarity genes hedgehog, engrailed, and wingless, and of the segment identity genes cap and collar [2];
FF its activation is controlled by the combined activities of the head-gap genes buttonhead and spiracles and the pair-rule gene even skipped [2];
FF it therefore integrates inputs from both the head and trunk segmentation systems, which were previously considered as being essentially independent [2];
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DR TRANSPATH: MO000028790.
DR EMBL: X97803;
DR UniProtKB: P56721;
DR FLYBASE: FBgn0001319.
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RN [1]; RE0017446.
RX PUBMED: 9389446.
RA Garel S., Marin F., Mattei M. G., Vesque C., Vincent A., Charnay P.
RT Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system.
RL Dev. Dyn. 210:191-205 (1997).
RN [2]; RE0017574.
RX PUBMED: 10477305.
RA Crozatier M., Valle D., Dubois L., Ibnsouda S., Vincent A.
RT Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment.
RL Development 126:4385-4394 (1999).
RN [3]; RE0017575.
RX PUBMED: 8793297.
RA Crozatier M., Valle D., Dubois L., Ibnsouda S., Vincent A.
RT Collier, a novel regulator of Drosophila head development, is expressed in a single mitotic domain.
RL Curr. Biol. 6:707-718 (1996).
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//