AC T05055
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ID T05055
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DT 01.03.2002 (created); mas.
CO Copyright (C), QIAGEN.
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FA COL-2
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SY COL; COL isoform 2; COL2; Collier; KN; knot.
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OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
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GE G003030 kn.
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HO COE1 (mouse), Olf-1 (rat).
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CL C0011; HLH.
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SZ 557 AA; 60.5 kDa (calc.).
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SQ MEWGRKLYPSAVSGPRSAGGLMFGLPPTAAVDMNQPRGPMTSLKEEPLGSRWAMQPVVDQ
SQ SNLGIGRAHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKT
SQ NNGIQYRLQLLYANGARQEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRC
SQ CDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVISTQVAVDGP
SQ LLAISDNMFVHNNSKHGRRAKRLDTTEGTGNTSLSISGHPLAPDSTYDGLYPPLPVATPC
SQ IKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGTMLVWSELITSHAIRVQTPPSDIPGVV
SQ EVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRLQKLIPRHPGDPEKLQKEIILKRA
SQ ADLVEALYSMPRSPDGSTGFNSYAGQLAVSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSS
SQ ASTPHSSGGSYGATAASAAVAATANGYAPAPNMGTLSSSPGSVFNSTSRVSSLSFNPFAL
SQ PTCNTQGYSTQLVTSTK
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SC translated from EMBL #X97803 and modified according to [3]
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FT 59 288 
DNA-binding domain [2].
FT 289 429 
dimerization domain [2].
FT 298 382 
SM00429; iptmega2.
FT 299 382 
PF01833; IPT/TIG domain.
FT 417 431 
type-2 HLH-related helix [1].
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SF existence of two isoforms COL1 T05041 and COL2 T05055 due to alternative splicing (3.9 and 3.4 kb) [3];
SF absence of one of the type-2 helices of the HLH-related motifs which is found in mouse homologs T01112, T05006 [1];
SF DNA-binding domain shows 85 % and 86 % amino acid identity to that of mouse homologs T05041 and T01112 [1] [3];
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CP (embryo:) peak at 8 h AEL [3]; (larvae, pupa:) high levels in L1, lower levels in L3, pupa [3] [3].
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FF required for normal embryonic head morphogenesis (second-level regulator in head patterning): reduction of its activity results in specific lack of head structures [3];
FF expression controlled by gap genes of the head [3];
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DR TRANSPATH: MO000028798.
DR EMBL: X97803;
DR UniProtKB: P56721;
DR FLYBASE: FBgn0001319.
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RN [1]; RE0017446.
RX PUBMED: 9389446.
RA Garel S., Marin F., Mattei M. G., Vesque C., Vincent A., Charnay P.
RT Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system.
RL Dev. Dyn. 210:191-205 (1997).
RN [2]; RE0017574.
RX PUBMED: 10477305.
RA Crozatier M., Valle D., Dubois L., Ibnsouda S., Vincent A.
RT Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment.
RL Development 126:4385-4394 (1999).
RN [3]; RE0017575.
RX PUBMED: 8793297.
RA Crozatier M., Valle D., Dubois L., Ibnsouda S., Vincent A.
RT Collier, a novel regulator of Drosophila head development, is expressed in a single mitotic domain.
RL Curr. Biol. 6:707-718 (1996).
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