AC T05052
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ID T05052
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DT 28.02.2002 (created); mas.
DT 15.12.2014 (updated); ros.
CO Copyright (C), QIAGEN.
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FA BTEB3
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SY basic transcription element binding protein 3; bte-binding protein 3; BTEB-3; erythroid transcription factor FKLF-2; FKLF-2; FKLF2; KLF13; Krueppel-like factor 13; Rantes factor of late activated T lymphocytes-1; RFLAT-1; transcription factor BTEB3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006340 Klf13.
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CL C0001; CH; 2.3.1.2.13.
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SF conflict in protein sequence between EMBL entry #AJ245644 and SWISSPROT entry #Q9JJZ6 at pos. 32 (R versus E) and pos. 43 (L versus P);
SF zinc fingers show 81 % amino acid identity to that of mouse homolog BTEB1 T04700 and 66 % to that of human homolog BTEB2 T02211 [1];
SF zinc fingers also show high amino acid identities to FKLF/TIEG family proteins, and at lower degree to SP1 and EKLF family proteins [2];
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EX aorta,,,adult; detectable; Northern blot; total RNA; [1].
EX brain,,,adult; detectable; RT-PCR; total RNA; [3].
EX heart,,,adult; detectable; Northern blot; total RNA; [1].
EX heart,,,adult; detectable; RT-PCR; total RNA; [3].
EX kidney (right and left),,,adult; detectable; Northern blot; total RNA; [1].
EX kidney (right and left),,,adult; detectable; RT-PCR; total RNA; [3].
EX large intestine,,,adult; detectable; Northern blot; total RNA; [1].
EX liver,,,adult; detectable; Northern blot; total RNA; [1].
EX liver,,,adult; low; RT-PCR; total RNA; [3].
EX lung,,,adult; detectable; RT-PCR; total RNA; [3].
EX mouse, Mus musculus,,,Theiler Stage 11; none; RT-PCR; total RNA; [1].
EX mouse, Mus musculus,,,Theiler Stage 14; detectable; RT-PCR; total RNA; [1].
EX mouse, Mus musculus,,,Theiler Stage 16; detectable; RT-PCR; total RNA; [1].
EX mouse, Mus musculus,,,Theiler Stage 21; detectable; RT-PCR; total RNA; [1].
EX mouse, Mus musculus,,,Theiler Stage 22; detectable; RT-PCR; total RNA; [1].
EX muscles,,,adult; detectable; RT-PCR; total RNA; [3].
EX small intestine,,,adult; detectable; Northern blot; total RNA; [1].
EX smooth muscle,vascular smooth muscle cell,,adult; detectable; Northern blot; total RNA; [1].
EX spleen,,,adult; detectable; Northern blot; total RNA; [1].
EX spleen,,,adult; detectable; RT-PCR; total RNA; [3].
EX stomach,,,adult; detectable; Northern blot; total RNA; [1].
EX testis (right and left),,,adult; low; RT-PCR; total RNA; [3].
EX uterus,,,adult; detectable; Northern blot; total RNA; [1].
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FF activator (e.g. on SM22alpha promoter) [1];
FF binds to GC-boxes [1];
FF activates promoters of globin genes that are characteristic for different development stages: epsilon (embryo), gamma (fetal) and beta (adult) globin [1];
FF upon induction of erythroid differentiation up-regulated in contrast to EKLF T01676 [2];
FF activates also non-globin erythroid gene promoters like GATA-1, GBP, FC, PBGD, ALAS even without typical GC-rich sequences [2];
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MX M05557 V$BTEB3_01.
MX M01865 V$BTEB3_Q5.
MX M07461 V$KLF_Q3.
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DR TRANSPATH: MO000028795.
DR UniProtKB: Q9JJZ6;
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RN [1]; RE0017586.
RX PUBMED: 10642511.
RA Martin K. M., Cooper W. N., Metcalfe J. C., Kemp P. R.
RT Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions
RL Biochem. J. 345:529-533 (2000).
RN [2]; RE0017587.
RX PUBMED: 10828046.
RA Asano H., Li X. S., Stamatoyannopoulos G.
RT FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes
RL Blood 95:3578-3584 (2000).
RN [3]; RE0017588.
RX PUBMED: 11087666.
RA Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P. L., Van Vooren P., Riviere M., Szpirer J., Szpirer C.
RT Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family
RL Genomics 70:93-101 (2000).
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