AC T05054
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ID T05054
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DT 28.02.2002 (created); mas.
DT 02.09.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA BTEB2
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SY basic transcription element binding protein 2; bte-binding protein 2; BTEB-2; BTEB2; IKLF; intestinal-enriched Krueppel-like factor; KLF5; Krueppel-like factor 5; transcription factor BTEB2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G003049 Klf5.
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CL C0001; CH; 2.3.1.2.5.
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SF conflict in protein sequence between EMBL entry #AF079852 and SWISSPROT entry #Q9Z0Z7 at pos. 23 (A versus D);
SF probably ortholog of human BTEB2 T02211 because there is 92 % amino acid identity for the overlapping region, however T02211 is much smaller with a length of only 219 amino acid [1];
SF does not appear to contain a transcriptional repressor domain like other members of this transcription factor family (Krueppel-like factors) [1];
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CP (embryo): expressed at E7 [1]; (adult:) highest levels in stomach, small intestine, and large intestine (proximal colon, distal colon, cecum) [1]; lower levels in uterus, placenta, skin, lung, testis [1]; in situ: epithelial layers of stomach, small intestine (enriched in epithelial cells in the middle crypt region), and colon [1] [1].
CN (embryo:) not detectable at E11, E15, E17 [1].
EX adipose tissue,,,adult; none; Northern blot; total RNA; [1].
EX base of Lieberk�hn's crypt of large intestine,epithelial cell,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX base of the Lieberk�hn's crypt of small intestine,epithelial cell,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX brain,,,adult; none; Northern blot; total RNA; [1].
EX caecum,,,adult; high; Northern blot; total RNA; [1].
EX distal colon,,,adult; high; Northern blot; total RNA; [1].
EX epithelial lamina of small intestine,,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX epithelial layer of colon,,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX epithelial layer of duodenum,,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX epithelial layer of gastrointestinal tract,epithelial cell,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX epithelial layer of stomach,,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX heart,,,adult; none; Northern blot; total RNA; [1].
EX kidney (right and left),,,adult; none; Northern blot; total RNA; [1].
EX large intestine,,,adult; high; Northern blot; total RNA; [1].
EX liver,,,adult; none; Northern blot; total RNA; [1].
EX lung,,,adult; low; Northern blot; total RNA; [1].
EX middle Lieberk�hn crypt region of large intestine,epithelial cell,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX middle Lieberk�hn crypt region of small intestine,epithelial cell,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 10; high; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 18; none; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 23; low; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 25; low; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; none; Northern blot; total RNA; [1].
EX placenta,,,adult; low; Northern blot; total RNA; [1].
EX proximal colon,,,adult; high; Northern blot; total RNA; [1].
EX skin,,,adult; low; Northern blot; total RNA; [1].
EX small intestine,,,adult; high; Northern blot; total RNA; [1].
EX spleen,,,adult; none; Northern blot; total RNA; [1].
EX stomach,,,adult; high; Northern blot; total RNA; [1].
EX testis (right and left),,,adult; low; Northern blot; total RNA; [1].
EX uterus,,,adult; low; Northern blot; total RNA; [1].
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FF activator [1] [2];
FF mediates transcriptional activation of the beta-globin promoter which contains 2 CACCC sites (a regulatory element bound by members of the Krueppel-like family of transcription factors) [1];
FF belongs to the class II zinc finger proteins which are expressed in a restricted number of tissues and during embryogenesis [1];
FF cooperates with NF-kappaB p50 for the activation of PDGF-A, most likely via direct protein-protein interactions [2];
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IN T08969 nanog; mouse, Mus musculus.
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MX M03814 V$BTEB2_Q3.
MX M07277 V$BTEB2_Q3_01.
MX M07461 V$KLF_Q3.
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DR TRANSPATH: MO000028797.
DR UniProtKB: Q9Z0Z7;
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RN [1]; RE0017590.
RX PUBMED: 9973612.
RA Conkright M. D., Wani M. A., Anderson K. P., Lingrel J. B.
RT A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells
RL Nucleic Acids Res. 27:1263-1270 (1999).
RN [2]; RE0023687.
RX PUBMED: 14573617.
RA Aizawa K., Suzuki T., Kada N., Ishihara A., Kawai-Kowase K., Matsumura T., Sasaki K., Munemasa Y., Manabe I., Kurabayashi M., Collins T., Nagai R.
RT Regulation of Platelet-derived Growth Factor-A Chain by Kruppel-like Factor 5: NEW PATHWAY OF COOPERATIVE ACTIVATION WITH NUCLEAR FACTOR-{kappa}B.
RL J. Biol. Chem. 279:70-76 (2004).
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