AC T05123
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ID T05123
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DT 22.05.2002 (created); mas.
DT 15.04.2009 (updated); sva.
CO Copyright (C), QIAGEN.
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FA TCFL4
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SY bigmax protein; max-like bHLHZip protein; mlx; tcfl4.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004139 Mlx.
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CL C0012; bHLH-ZIP; 1.2.6.6.1.
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SF probably group B HLH-protein that bind to CACGTG motif in DNA due to certain residues in DNA-binding domain (His at pos. 134, Glu at pos. 138, Arg at pos. 142) and thus homology to MAX T05056, T00489>, T01567 in this region [2] [4];
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EX brain,,,adult; detectable; RT-PCR; total RNA; [3].
EX colon,,,adult; detectable; RT-PCR; total RNA; [3].
EX duodenum,,,adult; detectable; RT-PCR; total RNA; [3].
EX heart,,,adult; detectable; RT-PCR; total RNA; [3].
EX ileum,,,adult; detectable; RT-PCR; total RNA; [3].
EX jejunum,,,adult; detectable; RT-PCR; total RNA; [3].
EX kidney (right and left),,,adult; detectable; RT-PCR; total RNA; [3].
EX liver,,,adult; detectable; RT-PCR; total RNA; [3].
EX lung,,,adult; detectable; RT-PCR; total RNA; [3].
EX muscles,,,adult; detectable; RT-PCR; total RNA; [3].
EX ovary,,,adult; detectable; RT-PCR; total RNA; [3].
EX pancreas,,,adult; detectable; RT-PCR; total RNA; [3].
EX salivary gland,,,adult; detectable; RT-PCR; total RNA; [3].
EX spleen,,,adult; detectable; RT-PCR; total RNA; [3].
EX stomach,,,adult; detectable; RT-PCR; total RNA; [3].
EX testis (right and left),,,adult; detectable; RT-PCR; total RNA; [3].
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FF subcellular location mainly in the cytoplasm because majority of protein found there after immunoprecipation of cell extracts (P19 cells) [4];
FF probably shuttles between nucleus and cytoplasm [4];
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IN T23085 Mad1; Mammalia.
IN T02392 Mad4; mouse, Mus musculus.
IN T18650 MondoA; mouse, Mus musculus.
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BS R12452.
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DR TRANSPATH: MO000032968.
DR UniProtKB: O08609;
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RN [1]; RE0017604.
RX PUBMED: 10593926.
RA Billin A. N., Eilers A. L., Queva C., Ayer D. E.
RT Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors.
RL J. Biol. Chem. 274:36344-36350 (1999).
RN [2]; RE0017805.
RX PUBMED: 9860302.
RA Meng X., Lu X., Li Z., Green E. D., Massa H., Trask B. J., Morris C. A., Keating M. T.
RT Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes
RL Hum. Genet. 103:590-599 (1998).
RN [3]; RE0017816.
RX PUBMED: 8973301.
RA Bjerknes M., Cheng H.
RT TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor
RL Gene 181:7-11 (1996).
RN [4]; RE0017817.
RX PUBMED: 11073985.
RA Billin A. N., Eilers A. L., Coulter K. L., Logan J. S., Ayer D. E.
RT MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network
RL Mol. Cell. Biol. 20:8845-8854 (2000).
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