AC T05174
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ID T05174
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DT 13.08.2002 (created); mas.
CO Copyright (C), QIAGEN.
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FA FOR1
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SY FOR; FOR 1; FOR-1; FXR-like orphan receptor; FXR-like orphan receptor 1.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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GE G004569 FOR1.
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HO FXR.
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CL C0002; CC (rec).
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SZ 513 AA; 58.2 kDa (calc.).
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SQ MRQWEDLEQTMANSYVTVSDAYCLAEPLSYYDVLPDHINYQLPESEFQTASCCQYTNMAY
SQ SPGLQSPSSQCHYTSYGLEAAYGDGQYLLSTCELSKPSTLMTHGVDDVYPSMKRPRGSHA
SQ SIRMKGHEELCVVCGDKASGYHYNALTCEGCKGFFRRSITKNAVYRCKNGGHCEMDMYMR
SQ RKCQECRLKKCKAVGMLAECLLTEVQCKSKRLRKNCKQNNSILSNVKVEDDGSDSRHVSS
SQ TTKLTKLPSQLELTGEECKLIDHIVTAHQKCGIPLDDLKIFLEESADPEEIFYHFSEAAM
SQ LHVQAFVEFTKRLPGFEMLDHEDQIALLKGSTVETMLLRSAQLYNQPATGSSLQSTEGLA
SQ RYQSHSVDFSQIQEFDRCPLYSLEANSHQVVSTSTTDLTEEFITPLFNFFRSMGSLNVTE
SQ AEYALLSAVTVLFSDRPLLQNKPPVEKLQEPLLGILHKYSKLYHPEDPQHFARLIGRLTE
SQ LRTLNHNHSEVLISWKARDTKLTPLLYGFWNLQ
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SC translated from EMBL #AF456451
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FT 1 130 
domain A/B [1].
FT 101 423 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 128 199 
SM00399; c4gold.
FT 128 203 
PS51030; NUCLEAR_REC_DBD_2.
FT 129 204 
PF00105; Zinc finger, C4 type (two domains).
FT 131 196 
domain C (DNA-binding domain) [1].
FT 197 513 
domain D/E/F [1].
FT 297 485 
SM00430; holi.
FT 300 509 
PF00104; Ligand-binding domain of nuclear hormon.
FT 355 417 
ligand-binding domain [1].
FT 364 396 unusual insertion in helix 7 of ligand-binding domain [1].
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SF paralogs FOR1 T05174 and FOR2 T05175 share 100% amino acid identity in DNA-binding domain and 91% in ligand-binding domain [1];
SF 89% amino acid identity in DNA-binding domain but only 45% in ligand-binding domain to rat FXR T04494 [1];
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CP (embryo, tadpole:) stage 30 (presumptive liver), higher levels at stage 35 and 36, lower levels at stage 41 [1]; (adult:) high levels in kidney, liver [1] [1].
CN (embryo, tadpole:) not before stage 30 and not after stage 41 [1].
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FF activator (in HEK 293 cells, when incubated with gallbladder extract) [1];
FF seems to be ligand-activated nuclear receptor because increase in transcriptional activate after incubation with gallbladder extract [1];
FF heterodimerization with RXR but probably no homodimerization and no heterodimerization with its paralog FOR2 T05175 [1];
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IN T01345 RXR-alpha; human, Homo sapiens.
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MX M00767 V$FXRIR1_Q6.
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BS R12767.
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DR TRANSPATH: MO000033002.
DR EMBL: AF456451;
DR UniProtKB: Q8JJ28;
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RN [1]; RE0017935.
RX PUBMED: 11867625.
RA Seo Y. W., Sanyal S., Kim H. J., Won D. H., An J. Y., Amano T., Zavacki A. M., Kwon H. B., Shi Y. B., Kim W. S., Kang H., Moore D. D., Choi H. S.
RT FOR, a novel orphan nuclear receptor related to farnesoid X receptor
RL J. Biol. Chem. 277:17836-17844 (2002).
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//