AC T05175
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ID T05175
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DT 13.08.2002 (created); mas.
CO Copyright (C), QIAGEN.
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FA FOR2
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SY FOR; FOR 2; FOR-2; FXR-like orphan receptor; FXR-like orphan receptor 2.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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GE G004570 FOR2.
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HO FXR.
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CL C0002; CC (rec).
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SZ 530 AA; 60.3 kDa (calc.).
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SQ MRQREQLEQTMANSYVTVSDAYCLAEPLTYYDVLPDHINYQLPDSEFQTASCCQYTNMAY
SQ SSGLQSPSSQCHYTSYGLEAAYGDGQYLLSTCELSKPSTYMTHSMDDVFPTMKRPRVSHT
SQ SIKVKGHEELCVVCGDKASGYHYNALTCEGCKGFFRRSITKNAVYRCKNGGHCEMDMYMR
SQ RKCQECRLKKCKAVGMLAECLLTEVQCKSKRLRKNCKQNNSILSNVKTEDDGSDSRHVSS
SQ TTKLTKLPSQLELTGEEYKLIDHIVTAHQKCGISLDDMKMFLEESADPEEIFYHFSEAAV
SQ LHVRAFVEFTKSLPGFEMLDPLDQIALLKASTVEAMLLRSAQIYNQSVMGSTLQTTEGLA
SQ RYPSHSVDFSQIQEFDKCPLYSLEAHPQEEDSTSSTDLTEEFITPLFNFFRSMGSLNVTE
SQ AEYALLSAVTVYFSDRPLLQSKPHVEKLQEPLLGILHKYSRLYHPEDPQHFARLIGRLTE
SQ LRTLHHNHSEVLVLWKARDTKLTPFAVWVLESTMSLESNCKFNLNLLQPA
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SC translated from EMBL #AF456452
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FT 1 130 
region A/B [1].
FT 101 504 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 128 199 
SM00399; c4gold.
FT 128 203 
PS51030; NUCLEAR_REC_DBD_2.
FT 129 204 
PF00105; Zinc finger, C4 type (two domains).
FT 131 196 
region C (DNA-binding domain) [1].
FT 297 485 
SM00430; holi.
FT 300 507 
PF00104; Ligand-binding domain of nuclear hormon.
FT 355 417 
ligand-binding domain [1].
FT 364 396 
unusual insertion in helix 7 of ligand-binding domain [1].
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SF paralogs FOR1 T05174 and FOR2 T05175 share 100% amino acid identity in DNA-binding domain and 91% in ligand-binding domain [1];
SF 15 additional C-terminal amino acids in comparison to FOR1 T05174 due to a single nucleotide insertion in the corresponding gene G004570;
SF 89% amino acid identity in DNA-binding domain but only 45% in ligand-binding domain to rat FXR T04494 [1];
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FF activator (in HEK 293 cells, when incubated with gallbladder extract) [1];
FF seems to be ligand-activated nuclear receptor because increase in transcriptional activate after incubation with gallbladder extract [1];
FF heterodimerization with RXR but probably no homodimerization and no heterodimerization with its paralog FOR1 T05174 [1];
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IN T01345 RXR-alpha; human, Homo sapiens.
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MX M00767 V$FXRIR1_Q6.
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BS R12767.
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DR TRANSPATH: MO000033003.
DR EMBL: AF456452;
DR UniProtKB: Q8JJ27;
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RN [1]; RE0017935.
RX PUBMED: 11867625.
RA Seo Y. W., Sanyal S., Kim H. J., Won D. H., An J. Y., Amano T., Zavacki A. M., Kwon H. B., Shi Y. B., Kim W. S., Kang H., Moore D. D., Choi H. S.
RT FOR, a novel orphan nuclear receptor related to farnesoid X receptor
RL J. Biol. Chem. 277:17836-17844 (2002).
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//