AC T05313
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ID T05313
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DT 25.10.2002 (created); oke.
DT 14.04.2009 (updated); sva.
CO Copyright (C), QIAGEN.
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FA FXR-isoform3:RXR-alpha
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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CL C0002; CC (rec).
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SF heterodimer;
SF for individual polypeptides see human FXR-isoform3 T05309 and human RXR-alpha T01345;
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FF activator, mediates gene induction by bile acids [1] [2] [3] [4];
FF typical DNA binding element is IR1;
FF takes part in lipid metabolism by up-regulating apoC2 gene [2];
FF regulates bile acid transport [3];
FF activates growth factor FGF19 gene [4];
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MX M00767 V$FXRIR1_Q6.
MX M07256 V$FXRRXR_Q5.
MX M01268 V$FXR_Q2.
MX M00631 V$FXR_Q3.
MX M03795 V$LXR_Q6.
MX M00964 V$PXR_Q2.
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BS R13129.
BS R19173.
BS R13128.
BS R09992.
BS R14233.
BS R10077.
BS R10075.
BS R10074.
BS R10076.
BS R13127.
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DR TRANSPATH: MO000033918.
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RN [1]; RE0018105.
RX PUBMED: 11706036.
RA Kast H. R., Goodwin B., Tarr P. T., Jones S. A., Anisfeld A. M., Stoltz C. M., Tontonoz P., Kliewer S., Willson T. M., Edwards P. A.
RT Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
RL J. Biol. Chem. 277:2908-2915 (2002).
RN [2]; RE0018115.
RX PUBMED: 11579204.
RA Kast H. R., Nguyen C. M., Sinal C. J., Jones S. A., Laffitte B. A., Reue K., Gonzalez F. J., Willson T. M., Edwards P. A.
RT Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.
RL Mol. Endocrinol. 15:1720-1728 (2001).
RN [3]; RE0018116.
RX PUBMED: 11387316.
RA Ananthanarayanan M., Balasubramanian N., Makishima M., Mangelsdorf D. J., Suchy F. J.
RT Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.
RL J. Biol. Chem. 276:28857-28865 (2001).
RN [4]; RE0023356.
RX PUBMED: 12815072.
RA Holt J. A., Luo G., Billin A. N., Bisi J., McNeill Y. Y., Kozarsky K. F., Donahee M., Wang da Y., Mansfield T. A., Kliewer S. A., Goodwin B., Jones S. A.
RT Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.
RL Genes Dev. 17:1581-1591 (2003).
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