AC T05676
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ID T05676
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DT 09.09.2003 (created); oke.
DT 24.12.2013 (updated); msr.
CO Copyright (C), QIAGEN.
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FA CAR:RXR-alpha
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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CL C0002; CC (rec).
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SF heterodimer;
SF for individual polypeptides see human CAR T02261 and human RXR-alpha T01345;
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FF activator;
FF binds to and activates transcription through different types of response elements;
FF may bind to DR5/RARE, DR4 [2] [3] [4];
FF may bind to DR3 [1];
FF may bind to ER6/IR6 [1] [4];
FF activates cyp2b and cyp3a genes in response to phenobarbital [4];
FF regulator of xenobiotic response in a complex interplay with PXR:RXR-alpha [1] [2] [3];
FF regulator of CYP2B, CYP3A, CYP2C cytochrome genes [1] [2] [3] [4];
FF CAR:RXR-alpha and PXR:RXR-alpha in several cases regulate common genes through the same DNA elements [1] [2] [3];
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MX M03788 V$CARRXR_Q2.
MX M00966 V$DR3_Q4.
MX M00965 V$DR4_Q2.
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BS R18174.
BS R18149.
BS R14174.
BS R14175.
BS R29205.
BS R29207.
BS R38351.
BS R14182.
BS R10090.
BS R28256.
BS R19287.
BS R59431.
BS R01321.
BS R14178.
BS R14179.
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DR TRANSPATH: MO000054367.
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RN [1]; RE0016457.
RX PUBMED: 11114890.
RA Xie W., Barwick J. L., Simon C. M., Pierce A. M., Safe S., Blumberg B., Guzelian P. S., Evans R. M.
RT Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
RL Genes Dev. 14:3014-3023 (2000).
RN [2]; RE0023235.
RX PUBMED: 11502872.
RA Goodwin B., Moore L. B., Stoltz C. M., McKee D. D., Kliewer S. A.
RT Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.
RL Mol. Pharmacol. 60:427-431 (2001).
RN [3]; RE0023246.
RX PUBMED: 11679585.
RA Gerbal-Chaloin S., Daujat M., Pascussi J. M., Pichard-Garcia L., Vilarem M. J., Maurel P.
RT Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.
RL J. Biol. Chem. 277:209-217 (2002).
RN [4]; RE0023334.
RX PUBMED: 10037683.
RA Sueyoshi T., Kawamoto T., Zelko I., Honkakoski P., Negishi M.
RT The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene.
RL J. Biol. Chem. 274:6043-6046 (1999).
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