AC T05967
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ID T05967
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DT 14.05.2004 (created); oke.
DT 06.12.2013 (updated); prb.
CO Copyright (C), QIAGEN.
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FA myocardin
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SY MYCD; MyoCD; transcription factor myocardin.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009492 Myocd.
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SF belongs to the SAP (SAF-A/B, Acinus, PIAS) domain family of nuclear proteins;
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CP aortic smooth muscle cells, A7r5 and A404 [2].
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FF activator;
FF regulates genes expressed in smooth muscle cells;
FF interacts with SRF T00766 and can be displaced by Elk-1 T05966 [1];
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IN T00766 SRF; rat, Rattus norvegicus.
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DR TRANSPATH: MO000041974.
DR UniProtKB: Q8R5I7;
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RN [1]; RE0024249.
RX PUBMED: 15014501.
RA Wang Z., Wang D. Z., Hockemeyer D., McAnally J., Nordheim A., Olson E. N.
RT Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.
RL Nature 428:185-189 (2004).
RN [2]; RE0024260.
RX PUBMED: 12663482.
RA Yoshida T., Sinha S., Dandre F., Wamhoff B. R., Hoofnagle M. H., Kremer B. E., Wang D. Z., Olson E. N., Owens G. K.
RT Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes.
RL Circ. Res. 92:856-864 (2003).
RN [3]; RE0047869.
RX PUBMED: 16151017.
RA Doi H., Iso T., Yamazaki M., Akiyama H., Kanai H., Sato H., Kawai-Kowase K., Tanaka T., Maeno T., Okamoto E., Arai M., Kedes L., Kurabayashi M.
RT HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.
RL Arterioscler. Thromb. Vasc. Biol. 25:2328-2334 (2005).
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