AC T00766
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ID T00766
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DT 15.10.1992 (created); ewi.
DT 14.06.2011 (updated); pch.
CO Copyright (C), QIAGEN.
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FA SRF
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SY serum response factor (c-fos serum response element-binding transcription factor); Serum Responsive Factor; SRF.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G090485 Srf.
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CL C0014; MADS.
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SF identified as a nuclear activity;
SF MADS box is necessary for the interactions with TEF-1 [4];
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FF activator;
FF regulates a number of muscle-specific genes;
FF in vitro and in vivo phosphorylation by casein kinase II, leading to induction of c-fos;
FF interactions with myocardin and Elk-1 in smooth muscle cells A7r5 are mutually exclusive [3];
FF functionally cooperates and forms a ternary complex on DNA with GATA-4 [5];
FF functionally cooperates and physically interacts with TEA-domain factor TEF-1 [4];
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IN T00043 Arg80p; yeast, Saccharomyces cerevisiae.
IN T00250 Elk-1; human, Homo sapiens.
IN T05966 Elk-1; rat, Rattus norvegicus.
IN T05967 myocardin; rat, Rattus norvegicus.
IN T01413 Net; mouse, Mus musculus.
IN T00737 SAP-1a; human, Homo sapiens.
IN T02128 SAP-1b; human, Homo sapiens.
IN T01124 TEF-1; mouse, Mus musculus.
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MX M00152 V$SRF_01.
MX M01257 V$SRF_02.
MX M00215 V$SRF_C.
MX M07618 V$SRF_Q3.
MX M00810 V$SRF_Q4.
MX M00922 V$SRF_Q5_01.
MX M01007 V$SRF_Q5_02.
MX M00186 V$SRF_Q6.
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BS R14851.
BS R00031.
BS R09705.
BS R09538.
BS R14834.
BS R14835.
BS R14816.
BS R14817.
BS R09532.
BS R09541.
BS R09597.
BS R14840.
BS R14841.
BS R15858.
BS R16448.
BS R09706.
BS R14706.
BS R14882.
BS R14883.
BS R14955.
BS R14956.
BS R02246.
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DR TRANSPATH: MO000025160.
DR TRANSCOMPEL: C00429.
DR TRANSCOMPEL: C00430.
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RN [1]; RE0000533.
RX PUBMED: 1915270.
RA Gauthier-Rouviere C., Basset M., Blanchard J.-M., Cavadore J.-C., Fernandez A., Lamb N. J. C.
RT Casein kinase II induces c-fos expression via the serum response element pathway and p67SRF phosphorylation in living fibroblasts
RL EMBO J. 10:2921-2930 (1991).
RN [2]; RE0002286.
RX PUBMED: 2928331.
RA Levi B.-Z., Kasik J. W., Burke P. A., Prywes R., Roeder R. G., Appella E., Ozato K.
RT Neonatal induction of a nuclear protein that binds to the c-fos enhancer
RL Proc. Natl. Acad. Sci. USA 86:2262-2266 (1989).
RN [3]; RE0024249.
RX PUBMED: 15014501.
RA Wang Z., Wang D. Z., Hockemeyer D., McAnally J., Nordheim A., Olson E. N.
RT Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.
RL Nature 428:185-189 (2004).
RN [4]; RE0025059.
RX PUBMED: 11136726.
RA Gupta M., Kogut P., Davis F. J., Belaguli N. S., Schwartz R. J., Gupta M. P.
RT Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1.
RL J. Biol. Chem. 276:10413-10422 (2001).
RN [5]; RE0025060.
RX PUBMED: 11158291.
RA Morin S., Paradis P., Aries A., Nemer M.
RT Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor.
RL Mol. Cell. Biol. 21:1036-1044 (2001).
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