AC T01413
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ID T01413
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DT 11.12.1994 (created); ewi.
DT 17.06.2013 (updated); sup.
CO Copyright (C), QIAGEN.
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FA Net
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SY Elk-3; ERP; Net; SAP2; SRF accessory protein 2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009412 Elk3.
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CL C0016; ETS.
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SZ 409 AA; 44.5 kDa (cDNA) (calc.).
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SQ MESAITLWQFLLHLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLS
SQ RALRYYYDKNIIKKVIGQKFVYKFVSFPDILKMDPHAVEISRESLLLQDGDCKVSPEGRE
SQ VHRHGLSSLKSASRNEYLHSGLYSSFTINSLENAPEAFKAIKTEKLEEPCDDSPPVEEVR
SQ TVIRFVTNKTDKHITRPVMSLPSTSETAAAAASAFLASSVSAKISSLMLPNAASVSSVSP
SQ SSSRSPSLSPDSPLPSEHRSLFLEAACHESDSLEPLNLSSGSKTKSPSLPPKGKKPKGLE
SQ ISAPQLLLSGTDIGSIALNSPALPSGSLTPAFFTAQTPSGLFLASSPLLPSIHFWSSLSP
SQ VAPLSPARLQGPNTLFQFPTLLNGHMPVPLPSLDRAPSPVLLSPSSQKS
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SC translated from EMBL #Z32815
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FT 4 87 
PF00178; Ets-domain.
FT 4 89 
SM00413; etsneu2.
FT 5 85 
PS50061; ETS_DOMAIN_3.
FT 7 75 
PS50140; HSF_ETS.
FT 132 152 
B box (homology with Elk-1 and SAP-1): essential for ternary complex formation [1].
FT 345 409 
inhibition of DNA-binding [1].
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SF member of the elk subfamily of ETS factors;
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CP heart, muscle, lung; less in liver, kidney; low in brain [1], early B cells [2]; muscle, thymus, spleen, lung [5] [1] [5] [2].
CN spleen, testis [1].
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FF repressor [1];
FF activator as a downstream target of Ras [1];
FF ternary complex formation with SRF [1] [5];
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IN T10212 E47; Mammalia.
IN T00765 SRF-L; mouse, Mus musculus.
IN T00761 SRF; chick, Gallus gallus.
IN T00762 SRF; cat, Felis silvestris catus.
IN T00763 SRF; clawed frog, Xenopus laevis.
IN T00766 SRF; rat, Rattus norvegicus.
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MX M00971 V$ETS_Q6.
MX M01982 V$NET_01.
MX M03832 V$NET_Q6.
MX M08824 V$NET_Q6_01.
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BS R00466.
BS R16781.
BS R56499.
BS R01224.
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DR TRANSPATH: MO000041643.
DR EMBL: L19953;
DR EMBL: Z32815;
DR UniProtKB: P41971;
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RN [1]; RE0000802.
RX PUBMED: 7958835.
RA Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
RT Net, a new ets transcription factor that is activated by Ras
RL Genes Dev. 8:1502-1513 (1994).
RN [2]; RE0005336.
RX PUBMED: 7909357.
RA Lopez M., Oettgen P., Akbarali Y., Dendorfer U., Libermann T. A.
RT ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development
RL Mol. Cell. Biol. 14:3292-3309 (1994).
RN [3]; RE0013484.
RX PUBMED: 8918463.
RA Maira S. M., Wurtz J. M., Wasylyk B.
RT Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif.
RL EMBO J. 15:5849-5865 (1996).
RN [4]; RE0024168.
RX PUBMED: 14729959.
RA Nakade K., Zheng H., Ganguli G., Buchwalter G., Gross C., Wasylyk B.
RT The tumor suppressor p53 inhibits Net, an effector of Ras/extracellular signal-regulated kinase signaling.
RL Mol. Cell. Biol. 24:1132-1142 (2004).
RN [5]; RE0024210.
RX PUBMED: 9315625.
RA Giovane A., Sobieszczuk P., Ayadi A., Maira S. M., Wasylyk B.
RT Net-b, a Ras-insensitive factor that forms ternary complexes with serum response factor on the serum response element of the fos promoter.
RL Mol. Cell. Biol. 17:5667-5678 (1997).
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