AC T05989
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ID T05989
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DT 28.05.2004 (created); oke.
DT 11.11.2010 (updated); din.
CO Copyright (C), QIAGEN.
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FA deltaFosB
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SY short variant of FosB.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009540 FOSB; HGNC: FOSB.
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CL C0008; bZIP.
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SZ 338 AA; 35.9 kDa (cDNA) (calc.).
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SQ MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTA
SQ ITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGS
SQ GGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELT
SQ DRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRD
SQ LPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSY
SQ TSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL
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SC Swiss-Prot#P53539
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SF for animal models, see mouse deltaFosB T02198 and rat deltaFosB T05987;
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CP brain; vein endothelial cells [5].
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FF plays an important function in addiction of brain to drugs, for animal models see [2] [3] [4] [6];
FF in umbilical vein endothelial cells mRNA is induced by growth factors VEGF and PlGF [5];
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MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
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DR TRANSPATH: MO000042238.
DR UniProtKB: P53539; FOSB_HUMAN.
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RN [1]; RE0004889.
RX PUBMED: 1648531.
RA Mumberg D., Lucibello F. C., Schuermann M., Mueller R.
RT Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins
RL Genes Dev. 5:1212-1223 (1991).
RN [2]; RE0024325.
RX PUBMED: 9294222.
RA Hiroi N., Brown J. R., Haile C. N., Ye H., Greenberg M. E., Nestler E. J.
RT FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects.
RL Proc. Natl. Acad. Sci. USA 94:10397-10402 (1997).
RN [3]; RE0024326.
RX PUBMED: 10499584.
RA Kelz M. B., Chen J., Carlezon WA J. r., Whisler K., Gilden L., Beckmann A. M., Steffen C., Zhang Y. J., Marotti L., Self D. W., Tkatch T., Baranauskas G., Surmeier D. J., Neve R. L., Duman R. S., Picciotto M. R., Nestler E. J.
RT Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine.
RL Nature 401:272-276 (1999).
RN [4]; RE0024327.
RX PUBMED: 11572966.
RA Nestler E. J., Barrot M., Self D. W.
RT DeltaFosB: a sustained molecular switch for addiction.
RL Proc. Natl. Acad. Sci. USA 98:11042-11046 (2001).
RN [5]; RE0024333.
RX PUBMED: 14741347.
RA Holmes D. I., Zachary I.
RT Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors.
RL FEBS Lett. 557:93-98 (2004).
RN [6]; RE0024334.
RX PUBMED: 11268215.
RA Bibb J. A., Chen J., Taylor J. R., Svenningsson P., Nishi A., Snyder G. L., Yan Z., Sagawa Z. K., Ouimet C. C., Nairn A. C., Nestler E. J., Greengard P.
RT Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.
RL Nature 410:376-380 (2001).
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